Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

The humanistic burden of small cell lung cancer (SCLC): a systematic review of health-related quality of life (HRQoL) literature

Date

08 Oct 2016

Session

Poster Display

Presenters

Charlotte Panter

Citation

Annals of Oncology (2016) 27 (6): 493-496. 10.1093/annonc/mdw389

Authors

C. Panter1, B. Bennett1, Y. Yuan2, J. Penrod2

Author affiliations

  • 1 Pco, Adelphi Values Ltd, SK10 5JB - Bollington/GB
  • 2 World Wide Health Economics And Outcomes Research, Bristol-Myers Squibb, Princeton/US
More

Resources

Background

SCLC accounts for approximately 15% of all lung cancers and has a poorer prognosis and more aggressive course than other lung carcinomas. However, little is known about the humanistic burden of SCLC, specifically the impact on HRQoL. The objective of this study was to explore the impact of SCLC on HRQoL.

Methods

A systematic literature review was conducted using specific search terms in Medline® in process (PubMed), Embase, and PsycINFO. Searches were limited to human studies and the past 10 years (2005–March 2016). Additional pragmatic searches were conducted of oncology organisation websites and conference proceedings. A total of 373 articles were retrieved. Two reviewers independently screened titles and abstracts for eligibility. Fifty-eight articles were selected for full-text review, with 27 of these being deemed eligible for inclusion (clinical trials [n = 18], observational studies [n = 7], and qualitative studies [n = 2]).

Results

Most articles provided data on limited and extensive stage SCLC. The most commonly used patient-reported outcomes (PROs) to assess SCLC impact on HRQoL were the EORTC QLQ-C30 (n = 15), often supplemented by the lung or brain cancer module (n = 7), and the Lung Cancer Symptom Scale (n = 5). SCLC patients had significantly impacted overall HRQoL, which was lower than normative reference values. HRQoL deteriorated further as disease progressed. Specific HRQoL domains most commonly reported included activities of daily living (ADL; n = 11), and physical (n = 10), emotional (n = 10), and cognitive functioning (n = 9). Differential impacts on each of these domains were noted, with ADL being the most severely impacted and emotional and cognitive functioning being the least. There was a difference in HRQoL between clinical trial and real world studies. Not all therapies provided improved or stable HRQoL, which may be due to tolerability differences.

Conclusions

These findings show that SCLC progression and treatment have a substantial impact on overall HRQoL and some of the HRQoL subdomains. Further research on the impact on specific HRQoL domains is required. Capturing HRQoL data in SCLC may help patients and clinicians make informed treatment choices.

Clinical trial identification

Not applicable to this study

Legal entity responsible for the study

N/A

Funding

Bristol-Myers Squibb

Disclosure

C. Panter, B. Bennett: Research was sponsored by BMS. Y. Yuan, J. Penrod: Research was sponsored by BMS, co-author is an employee of BMS.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings