A study was conducted of serum hormone levels among girls from Pripyat and Kyiv 5 years after the Chornobyl accident. Variations of hormonal status in pre- and pubertal girls evacuated from the town Pripyat and girls from the city of Kyiv were this revealed.
We investigated the hormones in the blood serum of 749 girls from Pripyat (504) and Kyiv (245). Age girl was 10-15 years. The study was conducted in Kyiv with the support of Ukrainian-French medical center "Children of Chornobyl". Radioimmunoassay was used to determine the the blood serum hormones: testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), cortisol (F), triiodothyronine (T3) thyroxine (T4), progesterone (P4), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH).
In surveys of girls from Pripyat we established 7 statistically significant diferences in 7 hormone levels: T, FSH, LH, E2, PRL, F, T4. Serum of girls from Pripyat compared with serum of girls from Kyiv had levels of T, FSH, LH higher than in controls (p
Revealed abnormalities in the hormonal status of the girls surveyed, obviously, is the result of functional disorders of the endocrine system. Such dysfunction does not give explicit symptoms and thus remain unnoticed by the doctor. The girls identified with hormonal disorders, obviously, are a group at high risk for the occurrence of tumors caused by hormones.
Clinical trial identification
Legal entity responsible for the study
Ukrainian-French medical center "Children of Chornobyl", NAS of Ukraine
All authors have declared no conflicts of interest.