Recent molecular profiling has identified a growing number of mutations that are considered targetable in metastatic colorectal cancer (mCRC). We aimed to explore the genomic complexity of metastatic colorectal tumors by patient factors such as age, gender, race, and site of primary tumor using next-generation sequencing (NGS).
We conducted a retrospective study based on comprehensive genomic profiling of tumors from patients (pts) with predominantly mCRC at our single institution using NGS via FoundationOne. All classes of genomic alterations were identified and their frequencies analyzed according to age (
Among 210 tumors that underwent FoundationOne analysis, frequencies of the following mutations in pts
There is increased genomic complexity observed in several molecular alterations of potential significance in mCRC based on age, gender, race, and site of primary tumor. These findings inform ongoing studies of larger size and prospective design that aim to analyze molecular signatures in metastatic colorectal tumors and their significance to prognosis and therapeutic targeting.
Clinical trial identification
Legal entity responsible for the study
City of Hope
City of Hope
All authors have declared no conflicts of interest.