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The correlation between tumor regression grade and retrieved lymph nodes status in locally advanced rectal cancer after neoadjuvant treatment: results from a prospective study

Date

08 Oct 2016

Session

Poster Display

Presenters

Jianwei Zhang

Citation

Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370

Authors

J. Zhang1, Y. Deng1, Y. Cai1, H. Hu1, J. Ling1, J. Xiao1, P. Lan2, L. Wang2, M. Huang2, L. Kang2, X. Wu2, J. Wang2

Author affiliations

  • 1 Medical Oncology, The Sixth Affiliated Hospital of Sun Yat-sen University, 510655 - Guangzhou/CN
  • 2 Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 510655 - Guangzhou/CN
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Background

A paucity of lymph nodes harvested is common in rectal cancer after neoadjuvant treatment and the significance is still uncertain. We aimed to evaluate the correlation between tumor regression grade (TRG) and retrieved lymph nodes status in patients who underwent neoadjuvant treatment followed by total mesorectal excision (TME) for locally advanced rectal cancer.

Methods

From Jan 2011 to Feb 2015, complete data was available for 447 patients with rectal cancer who received neoadjuvant treatment followed by TME enrolled in FOWARC study. According to the post-operative pathologic TRG of primary lesion, patients were categorized into 4 groups, TRG 0, 1, 2 and 3.The number of harvested lymph nodes, lymph node metastasis, and extranodal tumor deposits in each group were analyzed.

Results

Of the 447 patients, 77 (17.2%) patients were TRG 0, and 143 (32.0%) patients were TRG 1. Another 156 (34.9%) and 71 (15.9%) patients were TRG 2 and TRG 3, respectively. The median retrieved lymph node counts among the 4 groups were 8, 10, 11 and 13, respectively. The harvested lymph node in better TRG groups was less than that of poor TRG group (p = 0.001). The lymph node metastasis rates of the 4 groups were 7.8%, 14.7%, 21.8% and 38.0%, respectively. The differences were statistically significant (p 

Conclusions

Lymph node metastasis and extranodal tumor deposits were correlated with TRG. The paucity of lymph nodes retrieved did not infer poor oncologic outcomes in rectal cancer after neoadjuvant treatment. The number of retrieved lymph nodes should be redefined according to the pathologic response to neoadjuvant treatment. Further analysis of optimal lymph node counts in different TRG group will be performed with survival data.

Clinical trial identification

ClinicalTrials.gov Identifier: NCT01211210, and release data:28,September, 2010.

Legal entity responsible for the study

Yanhong Deng

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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