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Poster display

4175 - TERT as a prognostic factor for gliomas progression-free survival (PFS)


09 Oct 2016


Poster display


Maria Pilar Solis Hernandez


Annals of Oncology (2016) 27 (6): 103-113. 10.1093/annonc/mdw367


M.P. Solis Hernandez1, L. Faez1, D. Cantero2, A. Hernandez Lain2, P. Sanchez Gomez2, Y. Ruano2, M.D.M. Galera3, J.M. Sepúlveda Sánchez3

Author affiliations

  • 1 Medical Oncology, Hospital Universitario Central de Asturias, 33011 - Oviedo/ES
  • 2 Multidisciplinar Neurooncology Unit, University Hospital 12 De Octubre, 28041 - Madrid/ES
  • 3 Medical Oncology, University Hospital 12 De Octubre, 28041 - Madrid/ES


Abstract 4175


High frequencies of TERT promoter mutations have been described in gliomas. This underlies telomere maintenance upregulating telomerases. The mutation rate is higher in glioblastomas (GBM).


Observational and retrospective analysis of 100 patients with different histological types of gliomas. TERT mutations were determined by RT-PCR in brain tumor samples obtained from paraffin-embedded tissue. Survival analysis was performed with Kaplan-Meier curves compared by Log-Rank test.


There were included 52% GBM, oligodendrogliomas (OO) 12% and astrocytomas (AA) 29% each, and oligoastrocytomas (OA) 7%. The highest rate of TERT mutation was achieved in the OO group (66.7%) followed by GBM (55.8%) and AA (27.6%). From the 46% patients with TERT mutation: GBM 63%, OO and AA each 17.4%. Median relapse/progression free survival was 37, 33 and 7 months for AA, OO, OA and GBM respectively if wild type TERT, while if mutated 14, 20 and 8 months. TERT and ATRX seem to be mutually exclusive as there were only 2% coincidences.

Wild type TERT Mutated TERT
Median PFS Range Median PFS Range
Astrocytoma 37.6 124 14.2 120
Glioblastoma 7.1 37 8.8 42
Oligoastrocytoma 19.3 73 82.7 0
Oligodendroglioma 33.1 34 20.7 98


TERT mutations are determinant prognostic factors in glioma biology of both high and low grade.

Clinical trial identification

Legal entity responsible for the study

Hospital Universitario 12 de Octubre: Multidisciplinar Neurooncology Unit


Hospital Universitario 12 de Octubre: Multidisciplinar Neurooncology Unit


All authors have declared no conflicts of interest.

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