Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display

4175 - TERT as a prognostic factor for gliomas progression-free survival (PFS)

Date

09 Oct 2016

Session

Poster display

Presenters

Maria Pilar Solis Hernandez

Citation

Annals of Oncology (2016) 27 (6): 103-113. 10.1093/annonc/mdw367

Authors

M.P. Solis Hernandez1, L. Faez1, D. Cantero2, A. Hernandez Lain2, P. Sanchez Gomez2, Y. Ruano2, M.D.M. Galera3, J.M. Sepúlveda Sánchez3

Author affiliations

  • 1 Medical Oncology, Hospital Universitario Central de Asturias, 33011 - Oviedo/ES
  • 2 Multidisciplinar Neurooncology Unit, University Hospital 12 De Octubre, 28041 - Madrid/ES
  • 3 Medical Oncology, University Hospital 12 De Octubre, 28041 - Madrid/ES
More

Resources

Abstract 4175

Background

High frequencies of TERT promoter mutations have been described in gliomas. This underlies telomere maintenance upregulating telomerases. The mutation rate is higher in glioblastomas (GBM).

Methods

Observational and retrospective analysis of 100 patients with different histological types of gliomas. TERT mutations were determined by RT-PCR in brain tumor samples obtained from paraffin-embedded tissue. Survival analysis was performed with Kaplan-Meier curves compared by Log-Rank test.

Results

There were included 52% GBM, oligodendrogliomas (OO) 12% and astrocytomas (AA) 29% each, and oligoastrocytomas (OA) 7%. The highest rate of TERT mutation was achieved in the OO group (66.7%) followed by GBM (55.8%) and AA (27.6%). From the 46% patients with TERT mutation: GBM 63%, OO and AA each 17.4%. Median relapse/progression free survival was 37, 33 and 7 months for AA, OO, OA and GBM respectively if wild type TERT, while if mutated 14, 20 and 8 months. TERT and ATRX seem to be mutually exclusive as there were only 2% coincidences.

Wild type TERT Mutated TERT
Median PFS Range Median PFS Range
Astrocytoma 37.6 124 14.2 120
Glioblastoma 7.1 37 8.8 42
Oligoastrocytoma 19.3 73 82.7 0
Oligodendroglioma 33.1 34 20.7 98

Conclusions

TERT mutations are determinant prognostic factors in glioma biology of both high and low grade.

Clinical trial identification

Legal entity responsible for the study

Hospital Universitario 12 de Octubre: Multidisciplinar Neurooncology Unit

Funding

Hospital Universitario 12 de Octubre: Multidisciplinar Neurooncology Unit

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings