Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Systemic inflammation is associated with the density of immune cells in the tumor microenvironment of gastric cancer

Date

08 Oct 2016

Session

Poster Display

Presenters

Yeonjoo Choi

Citation

Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371

Authors

Y. Choi1, J.W. Kim1, K.H. Nam2, J. Kim3, S. Ahn4, D.J. Park4, K. Lee3, H.S. Lee5, H. Kim4

Author affiliations

  • 1 Department Of Internal Medicine, Seoul National University Bundang Hospital, 463-707 - Seongnam-si/KR
  • 2 Department Of Pathology, Inje University Haeundae Paik Hospital, Busan/KR
  • 3 Department Of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si/KR
  • 4 Department Of Surgery, Seoul National University Bundang Hospital, Seongnam-si/KR
  • 5 Department Of Pathology, Seoul National University Bundang Hospital, Seongnam-si/KR
More

Resources

Background

The neutrophil-lymphocyte ratio (NLR) and the prognostic nutritional index (PNI) are markers of systemic inflammation known to be useful prognostic indicators in the malignancy. However, no direct evidence has yet defined the influence of inflammation on the tumor microenvironment.

Methods

A total of 288 patients who underwent curative surgery for gastric cancer were included. Preoperative peripheral blood samples were used to analyze NLR and PNI. The optimal cut-off levels for NLR and PNI were defined using receiver operating characteristic curve analysis for survival (NLR = 2.7, PNI = 47.7). The densities of specific immune cells [CD3(+), CD4(+), CD8(+)] within the tumor microenvironment were measured in tumor microarrays by immunohistochemical analysis.

Results

There were 235 patients (81.6%) in low NLR and 53 patients (18.4%) in high NLR. Low PNI was identified in 117 patients (40.6%) and high PNI is in 171 patients (59.4%). CD3(+) and CD8(+) immune cell density were not associated with NLR and PNI. However, in high NLR group, CD4(+) immune cell density was significantly decreased compared to low NLR group (P 

Conclusions

In summary, NLR and PNI are associated with the density of CD4(+) immune cells in the tumor microenvironment, which leads to its prognostic values of systemic inflammation in gastric cancer.

Clinical trial identification

It is not clinical trial

Legal entity responsible for the study

Jin Won Kim

Funding

Seoul National University Bundang Hospital

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings