The prognosis of patients with advanced non-small cell lung
cancer (NSCLC) and coexisting chronic obstructive pulmonary disease (COPD) is uncertain. In addition, no previous studies have examined whether treating COPD improves the prognosis of such patients.
We focused our retrospective analysis on advanced NSCLC
patients who had received chemotherapy at Kyoto University Hospital between 2007 and 2014. The association between COPD treatment and overall survival (OS) was assessed using the log-rank test and Cox logistic regression models adjusted for age, sex, smoking, chemotherapy, the percentage forced expiratory volume in 1 second (%FEV1.0), and COPD treatment.
Of the 358 patients enrolled, 104 had COPD (COPD group) and
254 did not (non-COPD group). Thirty-seven patients in the COPD group had received COPD treatment. The median OS period was 323 days in the COPD group and 510 days in the non-COPD group (p
Coexisting COPD was associated with worse survival
outcomes in patients with advanced NSCLC. Our analysis indicated that COPD treatment might have potential to salvage the prognosis of such patients.
Clinical trial identification
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All authors have declared no conflicts of interest.