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Poster display

805 - Survival and functional outcomes of patients with metastatic solid organ cancer admitted to the intensive care unit of a general tertiary centre

Date

09 Oct 2016

Session

Poster display

Presenters

Francis Ha

Citation

Annals of Oncology (2016) 27 (6): 497-521. 10.1093/annonc/mdw390

Authors

F.J. Ha1, A.J. Weickhardt1, S. Parakh1, N.J. Glassford2, S. Warrillow2, D. Jones2

Author affiliations

  • 1 Department Of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Hospital, 3084 - Melbourne/AU
  • 2 Department Of Intensive Care Medicine, Austin Hospital, Melbourne/AU
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Resources

Abstract 805

Background

Studies of survival outcomes in metastatic solid organ cancer patients admitted to the intensive care unit (ICU) are limited, with no documentation of functional status following discharge. Furthermore, despite the poor long term outcome, documentation of advance care planning, including goals-of-care (GOC), is often sub-optimal.

Methods

We retrospectively assessed outcomes from patients with incurable metastatic solid organ malignancies non-electively admitted to a tertiary hospital ICU from January 2010 - June 2015. Patient demographics were collected and survival rates analysed and correlated with potential prognostic factors. Post-discharge living arrangements and functional status as assessed by Eastern Cooperative Group performance scores (ECOG) at 1- and 3-months were collected. GOC documentation specifying resuscitation status were collected.

Results

101 patients were treated in the ICU during the study period, with cancer treatment-related complications being the most common reason for admission (47%). The ICU, hospital, 30 day and 12 month mortality rates were 16%, 35%, 41% and 76%, respectively. On multiple-variable analysis, predictors of 30 day mortality were albumin

Conclusions

Survival is poor in patients with metastatic cancer and non-elective ICU admissions, although functional status of surviving patients often recovers by 3 months. Low albumin and ECOG status are simple prognostic markers for mortality in cancer patients. Discussions around advanced care planning need to be made early to avoid inappropriate ICU admissions and interventions given the poor survival rates.

Clinical trial identification

Legal entity responsible for the study

Austin Hospital

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.

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