Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Surgically treated esophageal cancer developed in a radiated field: Impact on peri-operative and long-term outcomes

Date

08 Oct 2016

Session

Poster Display

Presenters

Sheraz Markar

Citation

Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371

Authors

S.R. Markar1, C. Gronnier2, A. Pasquer3, A. Duhamel4, H. Behal4, J. Thereaux5, J. Gagniere6, G. Lebreton7, C. Brigand8, B. Meunier9, D. Collet10, C. Mariette2

Author affiliations

  • 1 Department Of Surgery & Cancer, St Mary's Hospital, Imperial College, W21NY - London/GB
  • 2 Dpt Of Digestive And Oncological Surgery, Lille University Hospital, France, 59037 - Lille/FR
  • 3 Dpt Of Digestive Surgery, Hopital Edouard Herriot Pav. E bis, Lyon/FR
  • 4 Department Of Biostatistics, DRC / CHRU of Lille, Lille/FR
  • 5 Dpt Of Digestive Surgery, Cavale Blanche University Hospital, Brest/FR
  • 6 Dpt Of Digestive Surgery, CHU Estaing, Clermont-Ferrand/FR
  • 7 Dpt Of Digestive Surgery, Côte de Nacre University Hospital, Caen/FR
  • 8 Dpt Of Digestive Surgery, C.H.U. Hautepierre, Strasbourg/FR
  • 9 Dpt Of Digestive Surgery, CHU de Pontchaillou, Rennes/FR
  • 10 Department Of Oeso-gastric And Endocrine Surgery, Centre Magellan Hôpital Haut-Lévêque, 33600 Pessac - Bordeaux/FR
More

Resources

Background

The objectives of this study were to compare peri-operative and long-term outcomes from esophageal cancer (EC) (i) that arose in a previously radiated field (ECRF) versus primary (PEC) and among ECRF patients (ii) radiotherapy-induced (RIEC) versus non radiotherapy-induced EC (NRIEC).

Methods

Data was collected from 30 European centers from 2000–2010. 2489 EC patients surgically treated were included in the PEC group and 136 in the ECRF group, including 61 in the NRIEC group and 75 in the RIEC group. Propensity score matching analyses were used to compensate for differences in baseline characteristics.

Results

Compared to the PEC group, the ECRF group was characterized by less use of neoadjuvant chemoradiotherapy (0% vs. 29.5%; P 

Conclusions

ECRF is associated with poorer long-term survival related to a reduced utilization of neoadjuvant chemoradiotherapy and an increased incidence of tumor margin involvement at surgery. Outcomes are dictated by the limitations related to previous radiotherapy administration more than the radiotherapy-induced carcinogenesis.

Clinical trial identification

Not applicable

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings