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Poster Display

2177 - Surgically treated esophageal cancer developed in a radiated field: Impact on peri-operative and long-term outcomes


08 Oct 2016


Poster Display


Sheraz Markar


Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371


S.R. Markar1, C. Gronnier2, A. Pasquer3, A. Duhamel4, H. Behal4, J. Thereaux5, J. Gagniere6, G. Lebreton7, C. Brigand8, B. Meunier9, D. Collet10, C. Mariette2

Author affiliations

  • 1 Department Of Surgery & Cancer, St Mary's Hospital, Imperial College, W21NY - London/GB
  • 2 Dpt Of Digestive And Oncological Surgery, Lille University Hospital, France, 59037 - Lille/FR
  • 3 Dpt Of Digestive Surgery, Hopital Edouard Herriot Pav. E bis, Lyon/FR
  • 4 Department Of Biostatistics, DRC / CHRU of Lille, Lille/FR
  • 5 Dpt Of Digestive Surgery, Cavale Blanche University Hospital, Brest/FR
  • 6 Dpt Of Digestive Surgery, CHU Estaing, Clermont-Ferrand/FR
  • 7 Dpt Of Digestive Surgery, Côte de Nacre University Hospital, Caen/FR
  • 8 Dpt Of Digestive Surgery, C.H.U. Hautepierre, Strasbourg/FR
  • 9 Dpt Of Digestive Surgery, CHU de Pontchaillou, Rennes/FR
  • 10 Department Of Oeso-gastric And Endocrine Surgery, Centre Magellan Hôpital Haut-Lévêque, 33600 Pessac - Bordeaux/FR


Abstract 2177


The objectives of this study were to compare peri-operative and long-term outcomes from esophageal cancer (EC) (i) that arose in a previously radiated field (ECRF) versus primary (PEC) and among ECRF patients (ii) radiotherapy-induced (RIEC) versus non radiotherapy-induced EC (NRIEC).


Data was collected from 30 European centers from 2000–2010. 2489 EC patients surgically treated were included in the PEC group and 136 in the ECRF group, including 61 in the NRIEC group and 75 in the RIEC group. Propensity score matching analyses were used to compensate for differences in baseline characteristics.


Compared to the PEC group, the ECRF group was characterized by less use of neoadjuvant chemoradiotherapy (0% vs. 29.5%; P 


ECRF is associated with poorer long-term survival related to a reduced utilization of neoadjuvant chemoradiotherapy and an increased incidence of tumor margin involvement at surgery. Outcomes are dictated by the limitations related to previous radiotherapy administration more than the radiotherapy-induced carcinogenesis.

Clinical trial identification

Not applicable

Legal entity responsible for the study





All authors have declared no conflicts of interest.

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