Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display

1382 - Risk factors for upper limb deep venous thrombosis (DVT) associated with peripherally inserted central catheters (PICCs) in cancer patients


09 Oct 2016


Poster display


Alvin Lee


Annals of Oncology (2016) 27 (6): 497-521. 10.1093/annonc/mdw390


A.J. Lee, B.P. Fairfax

Author affiliations

  • Oncology, Oxford Cancer and Haematology Centre, Churchill Hospital, OX3 7LE - Oxford/GB


Abstract 1382


Peripherally inserted central catheters (PICCs) are associated with an increased risk of upper limb deep vein thrombosis (DVT). In Oxford University Hospitals, PICCs are widely used for the delivery of chemotherapy in cancer patients. We aimed to investigate the incidence and risk factors for PICC-associated DVT in cancer patients.


This was a single centre study at a tertiary centre in Oxford. We obtained details of all patients who had PICCs inserted in 2015 under the vascular access department in the hospital. Gender, Body Mass Index (BMI), cancer type and chemotherapy regime were matched to these patients. A diagnosis of upper limb DVT was confirmed from diagnostic imaging. Retrospective analysis on the data was performed.


454 oncology patients had PICCs inserted in 2015. 18 patients (4%) developed a DVT. Gender proportions were similar between the DVT and non-DVT cohorts (72% female vs 73% female, p = 0.95). Median BMI was 27.43kg in those with DVTs and 26.84 in those without DVTs (p = 0.65). Breast cancer and colorectal cancer were the most common cancer types in the DVT cohort and breast cancer was over-represented whilst colorectal cancer under-represented compared to the non- DVT cohort (Table 1) (p = 0.59). A higher proportion of patients with DVTs received FEC-T chemotherapy compared to patients without DVTs (39% vs 25%, p = 0.20).

Cancer types in patients with DVTs and without DVTs

DVT (%) No DVT (%)
Breast cancer 8 (44) 165 (38)
Colorectal cancer 4 (22) 123 (28)
Other 6 (33) 148 (34)


Other studies have extensively analysed risk factors for PICC thrombosis but have not focused on types of cancer or chemotherapy. In our study, breast cancer and FEC-T chemotherapy appeared to be over-represented in the DVT cohort, however this did not reach statistical significance. We are currently performing further work using data from previous years to see if this trend continues.

Clinical trial identification

Legal entity responsible for the study

Oxford University Hospitals


Oxford University Hospitals


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings