Results of a prospective, multicenter, non-interventional trial to analyze disease- and treatment-related effects on the functionality of patients with gastrointestinal tumors ≥ 75 years

Date

08 Oct 2016

Session

Poster Display

Presenters

Jan Hofmann

Citation

Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371

Authors

J. Hofmann1, N. Härtel1, J. Hofmann1, M. Neugebauer1, A. Berger2, S. Zschäbitz2, H. Schulze-Bergkamen3, J. Betge1, S. Belle1, R. Jesenofsky1, N. Schulte1, U. Wedding4, M. Ebert1, J. Chi-Kern1

Author affiliations

  • 1 Ii. Medizinische Klinik, Universitätsklinikum Mannheim, 68167 - Mannheim/DE
  • 2 Medical Oncology, National Center for Tumor Diseases, Heidelberg/DE
  • 3 Department For Internal Medicine 2, Marien-Hospital Wesel, 46483 - Wesel/DE
  • 4 Department For Internal Medicine 2, Klinik fuer Innere Medizin II Klinikum der Friedrich- Schiller-Universitaet, 07743 - Jena/DE
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Background

Cancer is a disease of the elderly (average age of onset >69yrs). However, there is few data available on treatment- and disease-related interactions with the functional reserve of these patients (pts).

Methods

Prospective, multicenter non-interventional trial at two university hospitals in Germany. Included were pts ≥ 75yrs (n = 30) with gastrointestinal tumors receiving chemotherapy “ctx” in the period Q1/2015 - Q1/2016. To objectify the functionality of these pts sequential geriatric assessments (G8-Questionaire, ECOG, IADL, ADL) were performed. The analysis is based on data from 2 patient cohorts (C1: ctx 8 wks, n = 15).

Results

An initial dose reduction tended to stabilize the ADL/IADL of pts with newly initiated ctx (C1) when compared to those pts who received a 100%-dosage initially (p = 0,0986). Less ≥2° toxicities (tox) were detected after initial dose reduction (p = ns). However, at the time of the analysis the tox did not correlate with a deterioration in the IADL or ADL. Pts who started ctx with a pathological G8-Screening ( 8 wks (C2), a continued 100%-dosage did not result in a deterioration in the ADL/IADL (additionally no correlation between tox and the IADL/ADL has been detected). C2 pts with an intial G8 

Conclusions

These data suggest, that dose-escalating strategies maintain the functional reserve of pts ≥75yrs with gastrointestinal tumors. However disease control was the strongest predictor for stabilized functionality.

Clinical trial identification

AIO YMO project

Legal entity responsible for the study

N/A

Funding

Funded by the government

Disclosure

All authors have declared no conflicts of interest.

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