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Poster Display

2669 - Re-RAD-I external beam radiotherapy for pelvic recurrences in rectal cancer patients previously treated with radiotherapy


08 Oct 2016


Poster Display


Marianne Guren


Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370


M.G. Guren1, H.K. Christensen2, S.G. Larsen3, A.L. Appelt4, J. Lindegaard5, K.G. Spindler6

Author affiliations

  • 1 Department Of Oncology, Oslo University Hospital, 0450 - Oslo/NO
  • 2 Dept. Of Surgery, Aarhus University Hospital, Aarhus C/DK
  • 3 Dept. Of Surgery, Oslo University Hospital, Oslo/NO
  • 4 Dept. Of Oncology, Vejle Hospital, Vejle/DK
  • 5 Dept. Of Oncology, Aarhus University Hospital, Aarhus C/DK
  • 6 Dept. Of Oncology, Aarhus University Hospital, 8000 - Aarhus C/DK


Abstract 2669


Multimodal treatment of rectal cancer has improved outcome, but some patients still experience local recurrence, which is a major therapeutic challenge after previous radiotherapy (RT). Re-irradiation may improve the rate of radical surgery (R0), as reported in previous studies, where hyperfractionated chemo-RT resulted in 35% R0 rate. Surgery, RT techniques, and imaging have improved recent years, allowing for increased treatment precision with less morbidity. This study investigates re-irradiation of patients with local recurrence in a phase II clinical, imaging and translational study.

Trial design

A prospective multicenter phase II, open label, non-randomised study. Therapy: External beam RT of 40.8 Gy / 1.2 F BID by intensity-modulated RT + CBCT guidance, concomitant capecitabine 825 mg/m2 BID all RT days, and surgery 8 weeks post-RT. The primary endpoint is R0 rate. Secondary objectives: Recurrence-free, disease-free and overall survival, acute and late toxicity, patient reported outcomes, translational research, imaging studies for future adaptive RT, mapping of recurrences according to previous RT, and simulation studies of other RT modalities (proton therapy). Main inclusion criteria: Locally recurrent rectal cancer, previous pelvic RT and surgery, potentially resectable tumor, age ≥18 years, adequate organ function, acceptable bowel and bladder function, acceptance for translational research. Main exclusion criteria; central small recurrences deemed resectable, non-resectable distant metastases, medical comorbidities precluding radical surgery, previous RT

Clinical trial identification

Legal entity responsible for the study

Aarhus University Hospital


No external funding, it is an academic study. Clinical data collection and treatment-related costs will be covered by the local clinical trial unit/ department. Financial support for the sub-studies for translational research, imaging studies and treatment plan simulations will be funded independently, by external funding.


All authors have declared no conflicts of interest.

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