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Psychosocial quality of life in 30 survivors of bilateral retinoblastoma

Date

09 Oct 2016

Session

Poster display

Presenters

Atul Batra

Citation

Annals of Oncology (2016) 27 (6): 469-473. 10.1093/annonc/mdw386

Authors

A. Batra1, D. Dhawan1, S. Bakhshi2

Author affiliations

  • 1 Medical Oncology, All India Institute of Medical Sciences, 110029 - New Delhi/IN
  • 2 Medical Oncology, All India Institute of Medical Sciences, New Delhi/IN
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Resources

Abstract 2150

Background

Retinoblastoma (Rb) is the most common intraocular tumor in childhood. Approximately one-third of the cases are bilaterally affected. The cure rates have improved but the data on psychosocial quality of life are limited.

Methods

We analyzed the psychosocial domain quality of life (QOL) in 30 survivors of bilateral Rb using PedsQLTM 4.0 generic core scale in local language, which has been validated in the Indian population. The self-reported questionnaire was filled in by children of more than 5 years of age who had completed treatment for more than 12 months. The psychosocial aspect is represented by social, emotional and school domains of QOL. The QOL was compared with 25 siblings using student's t-test. Factors predicting QOL were assessed.

Results

The median age of Rb survivors was 86 (range, 61-190) months and male:female ratio was 3:1. The median age at diagnosis was 12 (range, 1-16) months. 83% (25/30) underwent enucleation of the worst eye, whereas both eyes could be preserved in 5 patients. All the patients received VEC (Vincristine, Etoposide and Carboplatin) based chemotherapy and the median number of chemotherapy cycles was 6 (range, 6-12). Radiotherapy was given in 8/30 (26%) patients. The psychosocial QOL was significantly worse in Rb survivors compared with controls. The emotional health domains of QOL (fear, anger and sleeping) were significantly lower in Rb survivors. Difficulties in maintaining friendships and competing were reported in the social health domain. In school health domain, there was significantly higher absenteeism due to sickness and hospital visits among Rb survivors. Age, sex, IRSS stage and previous radiotherapy did not affect the psychosocial QOL.

Comparison of psychosocial QOL of survivors of bilateral retinoblastoma and their siblings

Health Domain Rb Survivors (n = 30) Healthy Siblings (n = 25) P-value
Social 74.7 ± 10.1 83.9 ± 6.6 0.0003
Emotional 76.3 ± 9.6 82.5 ± 7.8 0.01
School 70.2 ± 11.2 84 ± 4.9

Conclusions

We found a significantly worse psychosocial QOL in bilateral Rb survivors, including the school, emotional and social aspects. However, no predicting factors for poor QOL were found.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.

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