Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display

2150 - Psychosocial quality of life in 30 survivors of bilateral retinoblastoma


09 Oct 2016


Poster display


Atul Batra


Annals of Oncology (2016) 27 (6): 469-473. 10.1093/annonc/mdw386


A. Batra1, D. Dhawan1, S. Bakhshi2

Author affiliations

  • 1 Medical Oncology, All India Institute of Medical Sciences, 110029 - New Delhi/IN
  • 2 Medical Oncology, All India Institute of Medical Sciences, New Delhi/IN


Abstract 2150


Retinoblastoma (Rb) is the most common intraocular tumor in childhood. Approximately one-third of the cases are bilaterally affected. The cure rates have improved but the data on psychosocial quality of life are limited.


We analyzed the psychosocial domain quality of life (QOL) in 30 survivors of bilateral Rb using PedsQLTM 4.0 generic core scale in local language, which has been validated in the Indian population. The self-reported questionnaire was filled in by children of more than 5 years of age who had completed treatment for more than 12 months. The psychosocial aspect is represented by social, emotional and school domains of QOL. The QOL was compared with 25 siblings using student's t-test. Factors predicting QOL were assessed.


The median age of Rb survivors was 86 (range, 61-190) months and male:female ratio was 3:1. The median age at diagnosis was 12 (range, 1-16) months. 83% (25/30) underwent enucleation of the worst eye, whereas both eyes could be preserved in 5 patients. All the patients received VEC (Vincristine, Etoposide and Carboplatin) based chemotherapy and the median number of chemotherapy cycles was 6 (range, 6-12). Radiotherapy was given in 8/30 (26%) patients. The psychosocial QOL was significantly worse in Rb survivors compared with controls. The emotional health domains of QOL (fear, anger and sleeping) were significantly lower in Rb survivors. Difficulties in maintaining friendships and competing were reported in the social health domain. In school health domain, there was significantly higher absenteeism due to sickness and hospital visits among Rb survivors. Age, sex, IRSS stage and previous radiotherapy did not affect the psychosocial QOL.

Comparison of psychosocial QOL of survivors of bilateral retinoblastoma and their siblings

Health Domain Rb Survivors (n = 30) Healthy Siblings (n = 25) P-value
Social 74.7 ± 10.1 83.9 ± 6.6 0.0003
Emotional 76.3 ± 9.6 82.5 ± 7.8 0.01
School 70.2 ± 11.2 84 ± 4.9


We found a significantly worse psychosocial QOL in bilateral Rb survivors, including the school, emotional and social aspects. However, no predicting factors for poor QOL were found.

Clinical trial identification

Legal entity responsible for the study





All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.