Abstract 3645
Background
No validated preoperative prognostic markers exist for pts with resectable gastric/GOJ adenocarcinoma (AC). There is evidence that NLR and platelet-to-lymphocyte ratio (PLR) predict outcomes in different types of malignancies. We aimed to explore the prognostic significance of NLR in pts with resectable gastric/GOJ AC undergoing perioperative chemotherapy.
Methods
In this retrospective cohort study, baseline neutrophil, lymphocyte and platelet blood count levels were recorded for all pts with resectable gastric/GOJ AC commenced on neoadjuvant ECX-based chemotherapy (Jul'09-Dec'14). The prognostic significance of baseline characteristics and blood count levels on overall survival (OS) and tumour resectability was tested by Cox-regression analysis. All comparisons were two-sided with level of significance p
Results
Of 368 pts included, 95 pts (26%) had gastric and 273 (74%) had GOJ primaries. ECOG Performance status (PS) was 0 in 133 (36%) and 1-2 in 235 pts (64%); 294 pts (80%) had curative surgery. After a median follow-up of 42 months (mo) (range 0.5-77) 209 (57%) pts were deceased. Increasing NLR associated with shorter OS (HR = 1.13, 95%CI = 1.06-1.19, p
Conclusions
NLR is highly prognostic in pts with resectable gastric/GOJ AC undergoing neoadjuvant ECX chemotherapy. We propose a baseline prognostic model that might inform prognosis and aid stratification of pts in clinical trials.
Clinical trial identification
n/a
Legal entity responsible for the study
The Christie NHS Foundation Trust
Funding
The Christie NHS Foundation Trust
Disclosure
All authors have declared no conflicts of interest.
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