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Prognostic significance of neutrophil to lymphocyte ratio (NLR) in patients (pts) with resectable gastric/gastroesophageal junction (GOJ) adenocarcinoma undergoing perioperative chemotherapy

Date

08 Oct 2016

Session

Poster Display

Presenters

Zena Salih

Citation

Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371

Authors

Z. Salih1, A.M. Conway2, G. Papaxoinis2, A. Patrao2, K. Fletcher2, R. Noble2, V. Owen-Holt2, W. Mansoor2

Author affiliations

  • 1 Medical Oncology, The Christie NHS Foundation Trust, M20 4BX - Manchester/GB
  • 2 Medical Oncology, The Christie NHS Foundation Trust, Manchester/GB
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Resources

Abstract 3645

Background

No validated preoperative prognostic markers exist for pts with resectable gastric/GOJ adenocarcinoma (AC). There is evidence that NLR and platelet-to-lymphocyte ratio (PLR) predict outcomes in different types of malignancies. We aimed to explore the prognostic significance of NLR in pts with resectable gastric/GOJ AC undergoing perioperative chemotherapy.

Methods

In this retrospective cohort study, baseline neutrophil, lymphocyte and platelet blood count levels were recorded for all pts with resectable gastric/GOJ AC commenced on neoadjuvant ECX-based chemotherapy (Jul'09-Dec'14). The prognostic significance of baseline characteristics and blood count levels on overall survival (OS) and tumour resectability was tested by Cox-regression analysis. All comparisons were two-sided with level of significance p 

Results

Of 368 pts included, 95 pts (26%) had gastric and 273 (74%) had GOJ primaries. ECOG Performance status (PS) was 0 in 133 (36%) and 1-2 in 235 pts (64%); 294 pts (80%) had curative surgery. After a median follow-up of 42 months (mo) (range 0.5-77) 209 (57%) pts were deceased. Increasing NLR associated with shorter OS (HR = 1.13, 95%CI = 1.06-1.19, p 

Conclusions

NLR is highly prognostic in pts with resectable gastric/GOJ AC undergoing neoadjuvant ECX chemotherapy. We propose a baseline prognostic model that might inform prognosis and aid stratification of pts in clinical trials.

Clinical trial identification

n/a

Legal entity responsible for the study

The Christie NHS Foundation Trust

Funding

The Christie NHS Foundation Trust

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

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