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Prognostic role for derived neutrophil-to-lymphocyte ratio in early breast cancer

Date

07 Oct 2016

Session

Breast cancer, early

Presenters

Alberto Ocana Fernandez

Citation

Annals of Oncology (2016) 27 (6): 43-67. 10.1093/annonc/mdw364

Authors

A. Ocana Fernandez1, A.J. Templeton2, M. Casas3, M. Sánchez-Aragó4, R. Caballero3, A. Rodríguez Lescure5, A. Ruiz6, E. Alba7, L. Calvo8, M. Ruiz9, A. Santaballa10, C. Rodríguez11, C. Crespo12, M. Ramos13, J.M. Gracia Marco14, A. Lluch-Hernandez15, I. Alvarez16, E. Carrasco3, E. Amir17, M. Martin18

Author affiliations

  • 1 Research Unit And Medical Oncology, Albacete University Hospital, 02006 - Albacete/ES
  • 2 Klinik Für Onkologie, St. Claraspital, 4058 - Basel/CH
  • 3 GEICAM (Spanish Breast Cancer Research Group), Madrid/ES
  • 4 Translational Research, GEICAM (Spanish Breast Cancer Research Group), Madrid/ES
  • 5 Medical Oncology, Hospital General Universitario de Elche, Alicante/ES
  • 6 Medical Oncology, Fundación Instituto Valenciano de Oncología, 46008 - Valencia/ES
  • 7 Hospital Universitario Regional Y Virgen De La Victoria, Instituto de Investigacion Biomedica de Malaga (IBIMA), 29010 - Malaga/ES
  • 8 Medical Oncology, 7Complejo Hospitalario Juan Canalejo, A Coruna/ES
  • 9 Medical Oncology, Hospital Universitario Virgen del Rocio, Sevilla/ES
  • 10 Medical Oncology, Hospital Universitari i Politècnic La Fe, 46026 - Valencia/ES
  • 11 Medical Oncology, Clínico de Salamanca Hospital, Salamanca/ES
  • 12 Medical Oncology, Hospital Universitario Ramon y Cajal, Madrid/ES
  • 13 Medical Oncology, Centro Oncologico de Galicia, A Coruna/ES
  • 14 Medical Oncology, Hospital de Cabueñes, Gijon/ES
  • 15 Serv. Hematologia Y Oncologia Medica, Hospital Clinico Universitario de Valencia, 46010 - Valencia/ES
  • 16 Medical Oncology Dept., Hospital Donostia, 20080 - San Sebastian/ES
  • 17 Medical Oncology, Princess Margaret Hospital, M5G 2M9 - Toronto/CA
  • 18 Medical Oncology, Canada17Instituto de Investigación Sanitaria Gregorio Marañón, Madrid/ES
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Resources

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Background

Inflammation is a hallmark of cancer. Elevated markers of host inflammation have been associated with worse outcomes in several solid tumors. Here, we explore the prognostic role of the derived neutrophil-to-lymphocyte ratio (dNLR) in subgroups of women with early breast cancer.

Methods

This was a retrospective analysis of women with early breast cancer included in the GEICAM/9906 trial, a randomized phase III study of adjuvant FEC compared to FEC-paclitaxel (FEC-P) in breast cancer patients with axillary involvement. dNLR was calculated as the ratio of neutrophils divided by the difference between total leukocytes and neutrophils measured in peripheral blood before the start of chemotherapy. The primary objective was disease free survival (DFS) and overall survival (OS) was a secondary endpoint. Univariable Cox regression was used to explore the prognostic and predictive value of dNLR (explored as median cutoff and grouped in quartiles). Subgroups by PAM50 subtype and hormonal receptor expression were subsequently analyzed.

Results

The current analysis comprised 1243 patients from 65 Spanish sites with a median follow-up of 10 years. Median age was 50 years (range 23-76), 66% of patients had available PAM50 subtype determination, of which 22% of the tumors were Luminal A, 21% Luminal B, 14% Her2-enriched, 6% Basal-like, and 3% Normal-like. ER+/PgR+ and ER/PgR subtypes comprised 47% and 13% of evaluable tumors, respectively. Median dNLR was 1.35 (IQR 1.08 – 1.71). For Her2-enriched patients by PAM50, a dNLR > median was significantly associated with worse DFS, p = 0.03 (HR: 1.63; 95%CI: 1.04 – 2.54). For non-luminal patients by PAM50, a dNLR > median and a high dNLR explored by quartiles were associated with worse DFS (p = 0.02 and p = 0.03, respectively). For patients with ER/PgR tumors, a high dNLR grouped in quartiles was associated with worse DFS and OS (p 

Conclusions

dNLR is associated with worse DFS in women with Her2-enriched and non-luminal intrinsic subtypes defined by PAM50 multigene expression assay. High dNLR is also associated with worse DFS and OS in women with ER-/PgR- tumors (IHC). Further studies are warranted to confirm these findings.

Clinical trial identification

Nº EudraCT: 2005-003108-12

Legal entity responsible for the study

GEICAM Spanish Breast Cancer Group

Funding

GEICAM Spanish Breast Cancer Group

Disclosure

All authors have declared no conflicts of interest.

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