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Poster Display

2840 - Prognostic implications of baseline neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in metastatic gastric cancer (GC) patients


08 Oct 2016


Poster Display


Angelica Petrillo


Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371


A. Petrillo, M.M. Laterza, J. Ventriglia, B. Savastano, G. Tirino, L. Pompella, E. Martinelli, F. Morgillo, M. Orditura, F. Ciardiello, F. De Vita

Author affiliations

  • Medical Oncology, AOU Seconda Università degli Studi di Napoli (AOU-SUN), 80131 - Napoli/IT


Abstract 2840


The outcome of metastatic gastric cancer is poor. Recent studies have shown that systemic inflammatory response markers such as NLR and PLR affect survival of GC pts. This study was carried out to create a prognostic model using inflammatory-based scores to predict survival in patients with metastatic GC before chemotherapy.


We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components in 110 pts with metastatic GC receiving first-line chemotherapy. NLR and PLR were determined before starting chemotherapy. Median value was used to determine the cut-off levels for these biomarkers. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Statistical analysis was performed by SPSS 21.0 software.


The median values of NLR and PLR were 2.22 (95% CI: 0.36-18.46) and 157.01 (95% CI: 32.79-720), respectively. Pts were divided into two groups according to the cut-off values (NLR:


This study suggests that elevated pretreatment NLR and PLR are independent predictors of short survival in metastatic GC patients treated with first-line chemotherapy.

Clinical trial identification

Legal entity responsible for the study

Fortunato Ciardiello


Second University of Naples


All authors have declared no conflicts of interest.

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