Prognostic implications of baseline neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in metastatic gastric cancer (GC) patients

Date

08 Oct 2016

Session

Poster Display

Presenters

Angelica Petrillo

Citation

Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371

Authors

A. Petrillo, M.M. Laterza, J. Ventriglia, B. Savastano, G. Tirino, L. Pompella, E. Martinelli, F. Morgillo, M. Orditura, F. Ciardiello, F. De Vita

Author affiliations

  • Medical Oncology, AOU Seconda Università degli Studi di Napoli (AOU-SUN), 80131 - Napoli/IT
More

Resources

Background

The outcome of metastatic gastric cancer is poor. Recent studies have shown that systemic inflammatory response markers such as NLR and PLR affect survival of GC pts. This study was carried out to create a prognostic model using inflammatory-based scores to predict survival in patients with metastatic GC before chemotherapy.

Methods

We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components in 110 pts with metastatic GC receiving first-line chemotherapy. NLR and PLR were determined before starting chemotherapy. Median value was used to determine the cut-off levels for these biomarkers. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Statistical analysis was performed by SPSS 21.0 software.

Results

The median values of NLR and PLR were 2.22 (95% CI: 0.36-18.46) and 157.01 (95% CI: 32.79-720), respectively. Pts were divided into two groups according to the cut-off values (NLR:

Conclusions

This study suggests that elevated pretreatment NLR and PLR are independent predictors of short survival in metastatic GC patients treated with first-line chemotherapy.

Clinical trial identification

Legal entity responsible for the study

Fortunato Ciardiello

Funding

Second University of Naples

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings