Prognosis of diffuse large B-cell lymphoma: 16 years of experience

Date

08 Oct 2016

Session

Poster Display

Presenters

Ece Esin

Citation

Annals of Oncology (2016) 27 (6): 313-327. 10.1093/annonc/mdw375

Authors

E. Esin1, A. Saglam2, M. Hayran3, A. Uner2

Author affiliations

  • 1 Medical Oncology Dep., Hacettepe University Faculty of Medicine, 06100 - Ankara/TR
  • 2 Pathology Dep., Hacettepe University Faculty of Medicine, 06100 - Ankara/TR
  • 3 Preventive Oncology, Hacettepe University Faculty of Medicine, 06100 - Ankara/TR
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Background

Diffuse large B-cell lymphoma (DLBCL) accounts for the majority of cases of non-Hodgkin's lymphoma in our country. However, little is known about its clinical and demographic data and prognosis. The aim of this study is to summarize the demographics and to investigate the prognosis of DLBCL patients from a tertiary reference hospital in Turkey over the past 16 years.

Methods

This study was designed as a retrospective cohort study. Patient who were diagnosed and/or treated at the University of Hacettepe between 1/2000 and 11/2015 were included. A chart review was conducted to access the clinical and demographic data. Main outcome measures [overall survival (OS), survival after progression (time from relapse to second progression or death, SAP)] were calculated.

Results

A total of 939 cases were included. Mean age of patients was 54 ± 17; 54% of the patients were male and 43.8% were female. Ann Arbor stages at presentation were as follows: stage-1 in 15.8% of patients, stage-2 in 23.4%, stage-3 in 21.1% and 39.7% as stage-4. It is of note that extranodal involvement was prominent (64.6%). The most prevelant extranodal sites were gastrointestinal system (17.3%), central nervous system (4.4%), bone (4.4%), skin (2.4%) and liver (2%). Mean overall survival was 94 ± 12.3 months. At 5 years, 93.2% of patients were alive and at 10 years 85.2% of patients were alive. There was a statistically significant survival difference between stage III and IV patients (p 

Conclusions

Extranodal presentation is more common in DLBCLs in Turkey and clinical parameters such as stage, EN status and BM involvement are the main prognostic factors.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

Authors

Disclosure

All authors have declared no conflicts of interest.

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