Platinum-fluoropyrimidine (PF) and paclitaxel (PTX)-based chemotherapy (CT) in advanced anal cancer (AC)

Date

08 Oct 2016

Session

Poster Display

Presenters

Francesco Sclafani

Citation

Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370

Authors

F. Sclafani1, F. Morano1, C. Baratelli1, E. Kalaitzaki2, D. Watkins1, N. Starling1, I. Chau1, D. Cunningham1, S. Rao1

Author affiliations

  • 1 Medicine, The Royal Marsden NHS Foundation Trust, SM2 5PT - Sutton/GB
  • 2 Research & Development, The Royal Marsden NHS Foundation Trust, SM2 5PT - Sutton/GB
More

Resources

Background

While treatment of localised AC is well established, there is paucity of data to inform the management of patient (pts) with advanced tumours. Thus we have retrospectively analysed treatment pathways and outcomes of a single institution series of advanced AC pts.

Methods

Inclusion criteria included epidermoid histology, inoperable locally recurrent or metastatic disease and availability of full medical records. The primary objective was overall survival (OS). Secondary objectives included objective response rate (ORR) and progression-free survival (PFS). Prognostic factors were analysed in a univariate model.

Results

From 1997 to 2014, 64 pts were seen at The Royal Marsden NHS Foundation Trust who met the eligibility criteria. Pt characteristics were: females (60.9%), median age 59.2 (IQR: 52.1-66.4), history of HIV infection (7.8%), squamous histology (90.6%), metastatic disease (75%), median time to advanced disease 9.1 months (m) (IQR: 4.1-20.9), prior pelvic radiotherapy (82.8%), prior salvage surgery (15.6%). 51 pts (79.7%) received ≥1 line of systemic CT. Of these, 37% also underwent multimodality treatment including surgery, chemoradiotherapy or radiofrequency ablation. PF was the most common regimen prescribed in the first-line setting (74.5%) with an ORR of 34.4% (95% CI: 18.6-53.2). PTX-based CT (single agent or combination therapy with carboplatin) was used in 15 pts as either front line or salvage treatment and the overall ORR was 53.3% (95% CI: 26.6-78.7). Median PFS after first- and second-line CT was 5.8m (IQR: 2.8-7.6) and 3.2m (IQR: 2.5-7.1), respectively. Median OS in CT-treated pts was 15.4m (IQR: 10.0-45.2) and 13% were alive at 5 years. Age ≤65 years and liver metastases were predictive of better PFS (HR 0.39; 95% CI: 0.16-0.97, p = 0.04) and worse OS (HR 2.25; 95% CI: 1.25-4.03, p = 0.01), respectively.

Conclusions

This is the second largest series of advanced AC ever reported. Doublet CT with PF and PTX-based CT are active regimens in this setting. Prospective clinical trials are needed to standardise treatment pathways, investigate the potential of novel therapeutics and ultimately improve the modest survival outcome of this pt population.

Clinical trial identification

not applicable

Legal entity responsible for the study

The Royal Marsden NHS Foundation Trust

Funding

The National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at the Royal Marsden NHS Foundation Trust and Institute of Cancer Research

Disclosure

I. Chau: Advisory roles with Merck Serono, Roche, Sanofi Oncology, Bristol Myers Squibb, Eli-Lilly, Novartis, Gilead Science. Research funding from Merck-Serono, Novartis, Roche and Sanofi Oncology. Honoraria from Roche, Sanofi-Oncology, Eli-Lilly, Taiho. D. Cunningham: Research funding from: Roche, Amgen, Celgene, Sanofi, Merck Serono, Novartis, AstraZeneca, Bayer, Merrimack and MedImmune. All other authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings