Biomarker from blood could be a useful and non-invasive tool to provide real-time information in the procedure of treatment.
To further understand the role of plasma mRNA in chemo-efficiency prediction, several mRNA levels were assessed in plasma and paired FFPE tumor tissues, and were correlated with chemosensitivity.
In the 133 patients with locally advanced gastric cancer (Stage III), significant correlations were observed between plasma and tumor mRNA levels of BRCA1(rho = 0.532, P
Plasma mRNA expression levels mirror those in the tumor and can be used as promising predictive biomarkers to predict chemo-efficiency.
Clinical trial identification
Legal entity responsible for the study
The Comprehensive Cancer Centre of Drum Tower Hospital
This work was funded by grants from the National Natural Science Foundation of China (Grant No. 81401969, 812101060 and 81300339.
All authors have declared no conflicts of interest.