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Plasma mRNA as liquid biopsy in individualized chemotherapy of gastric cancer

Date

08 Oct 2016

Session

Poster Display

Presenters

Jie Shen

Citation

Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371

Authors

J. Shen1, J. Wei1, X. Qian1, B. Liu2

Author affiliations

  • 1 Medical Oncology, The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, 210008 - Nanjing/CN
  • 2 Medical Oncology, The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing/CN
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Resources

Background

Biomarker from blood could be a useful and non-invasive tool to provide real-time information in the procedure of treatment.

Methods

To further understand the role of plasma mRNA in chemo-efficiency prediction, several mRNA levels were assessed in plasma and paired FFPE tumor tissues, and were correlated with chemosensitivity.

Results

In the 133 patients with locally advanced gastric cancer (Stage III), significant correlations were observed between plasma and tumor mRNA levels of BRCA1(rho = 0.532, P 

Conclusions

Plasma mRNA expression levels mirror those in the tumor and can be used as promising predictive biomarkers to predict chemo-efficiency.

Clinical trial identification

Legal entity responsible for the study

The Comprehensive Cancer Centre of Drum Tower Hospital

Funding

This work was funded by grants from the National Natural Science Foundation of China (Grant No. 81401969, 812101060 and 81300339.

Disclosure

All authors have declared no conflicts of interest.

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