Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display

1212 - Phase 1 study of LOXO-101, a selective TRK inhibitor, in pediatric patients with cancer

Date

10 Oct 2016

Session

Poster display

Presenters

Theodore Laetsch

Citation

Annals of Oncology (2016) 27 (6): 114-135. 10.1093/annonc/mdw368

Authors

T.W. Laetsch1, R. Nagasubramanian2, S.G. Dubois3, L. Mascarenhas4, D. Hawkins5, N. Shukla6, B. Turpin7, S. Smith8, M. Reynolds8, S. Cruickshank8, L. Donahue9, M.C. Cox8, A. Pappo10

Author affiliations

  • 1 Department Of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 - Dallas/US
  • 2 Pediatric Hematology/oncology, Nemours Children's Hospital, Orlando/US
  • 3 Dana-farber/boston Children’s Cancer And Blood Disorders Center, Boston Children's Hospital, Boston/US
  • 4 Department Of Oncology, Childrens Hospital Los Angeles University of Southern California, Los Angeles/US
  • 5 Department Of Hematology/oncology, Seattle Children's Hospital, Seattle/US
  • 6 Department Of Pediatrics, Memorial Sloan Kettering Cancer Center, New York/US
  • 7 Department Of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati/US
  • 8 Clinical Development, Loxo Oncology, Inc, 94107 - South San Francisco/US
  • 9 Clinical Operations, Loxo Oncology, Inc, 06901 - Stamford/US
  • 10 Solid Tumor Division, St Jude Children's Research Hospital, Memphis/US
More

Resources

Abstract 1212

Background

Neurotrophin ligands and their receptors TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3) are important for growth regulation, differentiation and survival of neurons. Translocations involving the NTRK1/2/3 kinase domain, mutations involving the TRK ligand-binding site, amplifications of NTRK, TRK splice variants, and autocrine/paracrine signaling have been described in diverse tumor types and may contribute to tumorigenesis. A broad range of pediatric malignancies have been found to harbor NTRK fusions, including infantile fibrosarcoma (IFS), congenital mesoblastic nephroma (CMN), secretory breast cancer, pediatric papillary thyroid cancer, pediatric gliomas and Ph-like acute lymphoblastic leukemia. Additionally, TRK protein over-expression is common in neuroblastoma. LOXO-101 is the first small-molecule selective inhibitor of TRKA, -B, and -C in clinical development and has demonstrated tumor inhibition in preclinical models and clinically meaningful responses in patients with TRK fusion cancers in an adult phase 1 trial.

Trial design

We have initiated an open-label, multi-center Phase I dose escalation/dose expansion study with LOXO-101 in pediatric patients with solid tumors and primary CNS tumors (NCT02637687). Patients with advanced cancer between the ages of 1 and 21 years are eligible, as well as patients as young as 1-month of age with a primary diagnosis of IFS or CMN and a documented NTRK fusion. Twice-daily oral dosing of LOXO-101 capsules is administered on a continuous 28-day schedule. LOXO-101 is available in an oral liquid formulation for patients unable to swallow capsules. PK-directed intra-subject dose escalation is permitted, with target exposures equivalent to the recommended Phase 2 dose in adults of 100 mg BID. Dose escalation utilizes a Rolling 6 design. The objective of the study is to determine the maximum tolerated dose and initial evidence of the efficacy of LOXO-101 in different tumor types. Eligibility for the dose expansion cohorts will require patient tumor samples to have documented alterations of an NTRK gene or TRK protein. Molecular abnormalities will be characterized through the analysis of archival tissue. Enrollment began in December 2015 and is ongoing.

Clinical trial identification

NCT02637687

Legal entity responsible for the study

Loxo Oncology, Inc.

Funding

Loxo Oncology, Inc.

Disclosure

S. Smith, M. Reynolds, S. Cruickshank: Paid consultant for Loxo Oncology. L. Donahue, M.C. Cox: Employee and stock holder of Loxo Oncology. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings