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Patterns of chemotherapy utilization in metastatic urothelial cancer (mUC): analysis from the retrospective international study of invasive/advanced cancer of the urothelium (RISC) database

Date

09 Oct 2016

Session

Poster display

Presenters

Aristotelis Bamias

Citation

Annals of Oncology (2016) 27 (6): 266-295. 10.1093/annonc/mdw373

Authors

A. Bamias1, K. Tzannis1, M. Liontos2, L. Harshman3, S.J. Crabb4, Y. Wong5, S.K. Pal6, T.B. Powles7, J. Bellmunt8, U. De Giorgi9, S. Ladoire10, N. Agarwal11, E.Y. Yu12, G. Niegisch13, C.N. Sternberg14, A. Alva15, S. Srinivas16, J. Rosenberg17, R. Investigators18

Author affiliations

  • 1 Clinical Therapeutics, National and Kapodistrian University of Athens, 115 28 - Athens/GR
  • 2 Oncology Unit, Department Of Clinical Therapeutics, Alexandra Hospital, 115 28 - Athens/GR
  • 3 Medical Oncology, Dana-Farber Cancer Institute, Boston/US
  • 4 Medical Oncology, University of Southampton, Southampton/GB
  • 5 Medical Oncology, Fox Chase Cancer Center, Philadelphia/US
  • 6 Medical Oncology And Experimental Therapuetics, City of Hope, 91010 - Duarte/US
  • 7 Department Of Medical Oncology, St. Bartholomew's Hospital, EC1A 7BE - London/GB
  • 8 Oncology, Dana-Farber Cancer Institute, Boston, MA/US
  • 9 Medical Oncology, Istituto Tumori della Romagna I.R.S.T., Meldola/IT
  • 10 Medical Oncology, Centre Georges-François Leclerc (Dijon), Dijon/FR
  • 11 Medical Oncology, Huntsman Cancer Institute, Salt Lake City/US
  • 12 Medical Oncology, Univ. Washington/VAPSHCS, Seattle/US
  • 13 Medical Oncology, Univesitätsklinikum Düsseldorf, Düsseldorf/DE
  • 14 Medical Oncology, Azienda Ospedaliera S. Camillo Forlanini, Roma/IT
  • 15 Medical Oncology, University of Michigan, East Lansing/US
  • 16 Medical Oncology, Stanford University, Palo Alto/US
  • 17 Medical Oncology, Memorial Sloan Kettering Cancer Center, New York/US
  • 18 Oncology, Mount SInai Medical College, New York/US
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Resources

Background

Cisplatin-based chemotherapy is the treatment of choice in mUC. A significant proportion of patients do not receive chemotherapy, while about 50% of treated patients do not receive cisplatin. We used the multinational RISC database to map patterns of chemotherapy utilization and adherence to recently published UFC criteria (Galsky, 2011) in unselected mUC patients

Methods

Selection criteria: diagnosis of mUC, transitional-cell, mixed, squamous and adeno histologies.

Results

Of 1974 mUC patients 475 (25%) did not receive 1st-line chemotherapy. No chemotherapy administration was associated with: non-pure TCC histology, higher Charslon Comorbidity Index (CCI), non-caucasian race, non-european country, low volume center (contribution of

Conclusions

Patterns of practice are influenced by various factors, such as age, co-morbidities, race, country of origin and volume of mUC patients. 25% of non-cisplatin treated patients were fit-for-cisplatin. Age and co-morbidities represent major factors, which lead to deviation from the established UFC criteria.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

Icahn School of Medicine, Mount Sinai USA

Disclosure

All authors have declared no conflicts of interest.

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