Clinical guidelines suggest that outpatient management of PE is an appropriate alternative in low-risk selected patients. However, this population is not adequately defined and the evidence is limited in cancer patients. Primary endpoint was the rate of success in outpatient PE management. Secondary endpoints included the analysis of complications and causes of readmission and mortality, re-thrombosis and major bleeding at 15, 30 and 90 days.
Epiphany is a Spanish multicenter ambispective and non-interventional study. It includes patients with cancer-associated PE, symptomatic and incidentally diagnosed, between October 2008 and October 2014. Patients were treated according to current international guidelines, and followed for at least 90-days. We present data from the cohort with LC.
We included 1033 patients with cancer and PE of whom 797 were diagnosed as outpatients. Of these, 210 had LC and 72 (34.3%) were discharged in the first 24-hours. 95.8% were incidental diagnoses and 83.3% did not show specific symptoms. The following features were associated with the last group (p
Within the limitations of an ambispective series and a subgroup analyses, this study suggest that most patients with LC and PE can be managed as outpatients, especially those with incidental PE. Additional studies are needed to better define the subgroup of patients at low risk of complications.
Clinical trial identification
Legal entity responsible for the study
Virgen del Rocio University hospital
All authors have declared no conflicts of interest.