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Poster Display

1807 - Molecular, clinical and prognostic characterization of double KRAS/PIK3CA (dKP) mutated metastatic colorectal cancer (mCRC)


08 Oct 2016


Poster Display


Julieta Grasselli


Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370


J. Grasselli1, E. Elez1, G. Argiles Martinez1, E. Sanz-Garcia1, T. Macarulla1, J. Capdevila1, M. Alsina1, T. Sauri1, C. Hierro1, H. Verdaguer1, I. Matos1, A. Garcia1, P. Nuciforo1, S. Landolfi1, H. Garcia Palmer1, R. Dienstmann2, A. Vivancos3, J. Tabernero1

Author affiliations

  • 1 Medical Oncology, Vall d`Hebron University Hospital Institut d'Oncologia, 08015 - Barcelona/ES
  • 2 Oncology Data Science, Vall d`Hebron University Hospital Institut d'Oncologia, 08035 - Barcelona/ES
  • 3 Genomics, Vall d`Hebron University Hospital Institut d'Oncologia, 08015 - Barcelona/ES


Abstract 1807


Molecular screening in mCRC has demonstrated an impact in treatment selection and outcome estimation. KRAS mutations (mut) frequently coexist with PIK3CA mut. Molecular, clinical and prognostic association of the dKP group has not been studied in detail.


657 mCRC patient records that were eligible for targeted mut profile were reviewed. From Jan 2010 – Jun 2014, mass spectrometry (Sequenom oncogene panel) was performed in 497 samples, and from Jul 2014 – Jul 2015, next generation sequencing (MiSeq amplicon oncogene and tumor suppressors panel) in 160.


dKP mut were found in 82 cases (12.5%), RAS/BRAF/PIK3CA wild type (wt) in 38.4%, RAS mut/PIK3CA wt 38.5%, RAS/BRAF wt/PIK3CA mut 3.4% and BRAF mut 7.2%. PIK3CA mut are enriched in KRAS mut as compared to RAS wt (25% vs. 9%, OR = 3.4, p 


The molecular features of dKP samples such as enrichment in particular KRAS/PIK3CA codons, less co-existing TP53 mut, together with their particular clinical characteristics suggest that the biology of these tumors is different from other genomically-defined groups. Nevertheless, co-occurrence of a PIK3CA mut on top of RAS mut does not significantly impact survival in the metastatic setting.

Clinical trial identification

Legal entity responsible for the study





J. Tabernero: Consultant/Advisory role: Amgen, Bayer, Boehringer Ingelheim, Celgene, Chugai, Lilly, MSD, Merck Serono, Novartis, Roche, Sanofi, Symphogen, Takeda, Taiho. All other authors have declared no conflicts of interest.

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