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MicroRNA-31 overexpression is able to predict pathological response and outcome in locally advanced rectal cancer

Date

08 Oct 2016

Session

Poster Display

Presenters

Cristina Carames

Citation

Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370

Authors

C. Carames1, I. Cristobal2, P. Minguez2, V. Moreno3, H. Callata-Carhuapoma1, A. Leon3, J.I. Martin3, M. Domine3, R. Hernandez3, M. Pedregal3, I. Martinez3, I. Moreno3, A. Correa3, F. Rojo4, J.M. García-Foncillas López3

Author affiliations

  • 1 Oncohealth Institute, University Hospital "Fundacion Jimenez Diaz", 28040 - Madrid/ES
  • 2 Translational Oncology-oncohealth Institute, University Hospital "Fundacion Jimenez Diaz", Madrid/ES
  • 3 Oncohealth Institute, University Hospital "Fundacion Jimenez Diaz", Madrid/ES
  • 4 Pathology, University Hospital "Fundacion Jimenez Diaz", 28040 - Madrid/ES
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Resources

Background

The treatment of choice for locally advanced rectal cancer is preoperative chemoradiotherapy (CRT). Despite around half of patients do not respond, suffer unnecessary toxicities and surgery delays, there are no biomarkers to guide preoperative CRT outcome. MicroRNA-31 (miR-31) has been related to acquisition of 5-fluorouracil resistance in rectal cancer however its potential predictive value of response to preoperative CRT in locally advanced rectal cancer remains unknown.

Methods

Eight-two patients diagnosed with locally advanced rectal cancer who were preoperatively treated with 5-fluorouracil based CRT were selected for this study. The miR-31 expression was quantified in formalin-fixed paraffin-embedded biopsies from this cohort previous to CRT therapy administration and the results obtained were correlated with clinical and molecular characteristics, pathological response and outcome.

Results

Overexpression of miR-31 was found in 34.2% of the cases. Its overexpression significantly predicted poor pathological response (p = 0.018) and worse overall survival (OS) (p = 0.008). Multivariate analysis confirmed the clinical significance of miR-31 in determining pathological response to neoadjuvant CRT as well as OS.

Conclusions

miR-31 quantification emerges as a novel valuable clinical tool to predict both pathological response and outcome in locally advanced rectal cancer patients.

Clinical trial identification

Legal entity responsible for the study

None

Funding

Fundación Jimenez Diaz

Disclosure

All authors have declared no conflicts of interest.

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