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Menopausal status on tumour biology in early breast cancer

Date

10 Oct 2016

Session

Poster display

Presenters

Olubukola Ayodele

Citation

Annals of Oncology (2016) 27 (6): 43-67. 10.1093/annonc/mdw364

Authors

O. Ayodele1, I. Ali1, A. Konenko1, L. Duggan1, N. O'Mara1, R. Rahman2, Y. Ged1, P. Calvert3, A. Horgan1, M. O'Connor1

Author affiliations

  • 1 Medical Oncology, University Hospital Waterford, x91 er8e - Waterford/IE
  • 2 Medical Oncology, St Vincents University Hospital, Dublin/IE
  • 3 Medical Oncology, University Hospital Waterford, Waterford/IE
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Background

Breast cancer (BC) is primarily a disease of older or post menopausal women. It has been suggested that BC arising in young women is a unique biological subset characterized by less hormone sensitivity and higher HER2 (epidermal growth factor receptor) expression. This study was performed to compare the tumour biology between pre menopausal (PrM) and post menopausal (PoM) women.

Methods

New diagnosis of early BC from 2011-2015 in the South East Cancer Centre were included. The patients were divided into PrM (

Results

Data from 497 patients were obtained. 235 (47.3%) were PrM and 262 (52.7%) were PoM. Age range PrM group vs PoM group (29-54 vs 55-91). The differences between the groups was statistically significant on pathology subtype (p = 0.003), T stage (p = 0.033), and N stage (p = 0.008). Ki67 and grade were not statistically significant. The mean ki67 across biology subtypes (ER/PR/HER2/Ki67) in the PrM group was higher. PrM group had more grade III disease (33.2% vs 30.9%). Table 1: Distribution of tumour biology according to menopausal status.

Pre Menopausal n = 235 Post Menopausal n = 262 P value
Age Range 29-54 55-91  

Conclusions

Pre menopausal women in this Irish population had poorer tumour biology compared to their Post menopausal counterpart. Aggressive measures should be taken in the treatment of these women to reduce the incidence of local recurrence and metastases.

Clinical trial identification

None

Legal entity responsible for the study

University Hospital Waterford

Funding

University Hospital Waterford

Disclosure

All authors have declared no conflicts of interest.

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