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Poster display

1790 - Is there an impact of body mass index on the breast cancer stage at initial diagnosis?

Date

10 Oct 2016

Session

Poster display

Presenters

Othman Akkar

Citation

Annals of Oncology (2016) 27 (6): 43-67. 10.1093/annonc/mdw364

Authors

O. Akkar, F. Mamouch, N. Berrada, M. El kabous, H. Errihani

Author affiliations

  • Oncologie Médicale, Institut National d'Oncologie Sidi Mohamed Ben Abdellah, 10000 - Rabat/MA
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Resources

Abstract 1790

Background

Some data suggest that there is a correlation between body mass index (BMI) and tumor stage in some biological subtypes. Others don't. The main objective of our study was to analyze the association between BMI and tumor stage according to the molecular profile.

Methods

Data were collected from the 2014 prospective database of breast cancer at the National Oncology Institute in Rabat. Morocco. The mass body index (BMI) was calculated by the formula: body weight (kg)/height (m2). SPSS was used for statistical Analysis, tests used are analysis of variance, comparison of mediums, and test Khi-two.

Results

481 patients were eligible. Medium of age was 48.9 years. 21.7% of tumors were HER2, 17.7% Triple negative and 60.6% luminal. The tumors were: T1 = 21.9%, T2 = 47.9% T3 = 11.7%, T4 = 12.7% Tx = 5.6%. For stages: I : 11.9%, IIA = 24.4%, IIB = 20.4%, IIIA = 15.8%, IIIB = 10.2%, IIIC = 10%, IV = 7.3%. The tumors grading: Grade 1 : 8.7%, Grade 2 : 57.9%, Grade 3 : 33.6% all correlation between BMI and other parameters and was negative even in triple negative cancers.

BMI Profile
Underweight 1%
Normal 26.5%
Overweight 35.0%
Obesity moderate 26.7%
Severe obesity 8.5%
Morbid obesity 2.3%
Statistical correlation between BMI and:
Tumor stage for all subtypes p = 0.29
Tumor size p = 0.096
Tumor stage for luminal cancers p = 0.48
Tumor stage for HER2 + cencers p = 0.33
Tumor stage for triple negative cancers p = 0.23
Expression estrogen hormone receptors p = 0.35
Expression progesterone hormone receptors p = 0.13
Expression HER2 p = 0.30

Conclusions

Our study suggests that there is no correlation between BMI and tumor stage regardless of the biological subtypes. Others studies are needed to confirm our results.

Clinical trial identification

Legal entity responsible for the study

National Institute of Oncology Rabat Morocco

Funding

National Institute of Oncology Rabat Morocco

Disclosure

All authors have declared no conflicts of interest.

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