Is there an impact of body mass index on the breast cancer stage at initial diagnosis?

Background

Some data suggest that there is a correlation between body mass index (BMI) and tumor stage in some biological subtypes. Others don't. The main objective of our study was to analyze the association between BMI and tumor stage according to the molecular profile.

Methods

Data were collected from the 2014 prospective database of breast cancer at the National Oncology Institute in Rabat. Morocco. The mass body index (BMI) was calculated by the formula: body weight (kg)/height (m2). SPSS was used for statistical Analysis, tests used are analysis of variance, comparison of mediums, and test Khi-two.

Results

481 patients were eligible. Medium of age was 48.9 years. 21.7% of tumors were HER2, 17.7% Triple negative and 60.6% luminal. The tumors were: T1 = 21.9%, T2 = 47.9% T3 = 11.7%, T4 = 12.7% Tx = 5.6%. For stages: I : 11.9%, IIA = 24.4%, IIB = 20.4%, IIIA = 15.8%, IIIB = 10.2%, IIIC = 10%, IV = 7.3%. The tumors grading: Grade 1 : 8.7%, Grade 2 : 57.9%, Grade 3 : 33.6% all correlation between BMI and other parameters and was negative even in triple negative cancers.

Conclusions

Our study suggests that there is no correlation between BMI and tumor stage regardless of the biological subtypes. Others studies are needed to confirm our results.

Clinical trial identification

Legal entity responsible for the study

National Institute of Oncology Rabat Morocco

Funding

National Institute of Oncology Rabat Morocco

Disclosure

All authors have declared no conflicts of interest.