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Poster display

3274 - Impact of the biological subtype on the risk of developing brain metastasis in Egyptian breast cancer patients


10 Oct 2016


Poster display


Loay Kassem


Annals of Oncology (2016) 27 (6): 68-99. 10.1093/annonc/mdw365


L. Kassem1, R. Abdel-Malek1, D. Abd El Moneim2, M. Ismail2, H.A. Azim3

Author affiliations

  • 1 Clinical Oncology, Cairo University, 35855 - Cairo/EG
  • 2 Medical Oncology, Cairo oncology center (Cairocure), 12311 - Cairo/EG
  • 3 Clinical Oncology Department, Cairo University, Cairo/EG


Abstract 3274


We aimed at investigating the impact of the biological subtype of breast cancer on the risk of developing brain metastasis and the outcome of Egyptian patients with brain metastasis.


We retrospectively reviewed the clinical records of 2193 consecutive women (1947 with localized disease and 246 with metastatic disease at presentation) diagnosed with breast cancer between January 1999 and December 2010. We explored the relationship between the clinico-pathological factors (including the biological subtypes) and the incidence of brain metastasis, Brain metastasis free survival (BMFS), and the Brain metastasis specific survival (BMSS).


Median follow up period for the whole cohort was 43.5 months (IQR 26-74 months); 160 patients (7.3%) developed brain metastasis. Among the individual clinico-pathological parameters, larger tumors (p = 0.006), axillary LN positivity (p 


Breast cancer biological subtype plays a pivotal role in predicting the pattern of failure of patients presenting with localized disease and the subsequent outcome after brain metastasis in addition to the classical prognostic factors.

Clinical trial identification

Legal entity responsible for the study

Cairo Oncology Center




All authors have declared no conflicts of interest.

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