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Poster display

3920 - Impact of sepsis and organ dysfunction on cancer patients' mortality


09 Oct 2016


Poster display


Filipa Pereira


Annals of Oncology (2016) 27 (6): 497-521. 10.1093/annonc/mdw390


F.M. Pereira1, S. Alves2, J. Dias2, I.M. Guerreiro2, M.J. Silva2, A. Afonso2, P. Mergulhão3, J. Savva-Bordalo2, D. Pereira1

Author affiliations

  • 1 Medical Oncology, Instituto Portugues de Oncologia Centro do Porto(IPO-Porto), 4200-072 PORTO - Porto/PT
  • 2 Medical Oncology, Instituto Portugues de Oncologia Centro do Porto(IPO-Porto), Porto/PT
  • 3 Intensive Care Medicine, HSJ - Hospital de São João, EPE, Porto/PT


Abstract 3920


Infection is a significant complication in cancer patients, which frequently prolongs hospitalization. Severe sepsis can also lead to acute organ dysfunction and eventually death. This study aimed to identify cancer patients with sepsis and organ dysfunction, and to assess its impact on mortality.


We reviewed medical data of cancer patients in a tertiary hospital, with diagnosis of sepsis, between January 2013 and April 2014. Descriptive analysis of main demographic, clinical and prognostic characteristics was performed. Identification of independent predictors of organ dysfunction and mortality was accomplished by binary logistic regression.


We included 257 patients with a median age of 67 years, 58% were male and 80% had a solid tumor: 25% gastrointestinal (GI), 18% lung and 16% genitourinary (GU). Half of patients presented a respiratory focus of infection and organ dysfunction were reported in 35% of patients. There was a significant association between primary tumor location and focus of infection (p 


Severe sepsis is a common and deadly complication in cancer patients. Focus of infection was related to primary tumor location. Number of organ dysfunction, hyperlactacidemia and MEDS score were associated to an increased risk of mortality. Nevertheless, more studies are needed to estimate of the magnitude of this problem, in order to improve medical management with positive impact for cancer survival.

Clinical trial identification

Legal entity responsible for the study

IPO-Porto, Hospital de São João


IPO-Porto, Hospital de São João


All authors have declared no conflicts of interest.

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