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Follow-up of chemotherapy induced changes in anti-Mullerian hormone, antral follicle number and ovary volume in premenopausal breast cancer patients

Date

10 Oct 2016

Session

Poster display

Presenters

Filiz Elbuken

Citation

Annals of Oncology (2016) 27 (6): 43-67. 10.1093/annonc/mdw364

Authors

F. Elbuken1, C. Ordu2, D. Sarsenov3, S. Ilgun4, K. Pilanci5, Z. Erdogan6, F. Agacayak7, G. Alco8, A. Ozturk9, Y. Eralp10, B. Baysal11, V. Ozmen12

Author affiliations

  • 1 Radiology, Ozel Gayrettepe Florence Nightingale Hospital, 34000 - Istanbul/TR
  • 2 Medical Oncology, Ozel Gayrettepe Florence Nightingale Hospital, 34000 - Istanbul/TR
  • 3 General Surgery, Istanbul Florence Nightingale Hospital, 34000 - Istanbul/TR
  • 4 General Surgery, Taksim Egitim Arastirma Hastanesi, 34000 - Istanbul/TR
  • 5 Medical Oncology, Haseki Education & Research Hopital, 34000 - Istanbul/TR
  • 6 Physical Therapy And Rehabilitation, Istanbul Bilim University-Shisane Campus, Istanbul/TR
  • 7 Radiology, Istanbul Florence Nightingale Hospital, Istanbul/TR
  • 8 Radiation Therapy, Ozel Gayrettepe Florence Nightingale Hospital, 34000 - Istanbul/TR
  • 9 General Surgery, Biruni University Medical Faculty, Istanbul/TR
  • 10 Medical Oncology, Istanbul University Medical Faculty, Istanbul/TR
  • 11 Obgyn, Istanbul Florence Nightingale Hospital, 34000 - Istanbul/TR
  • 12 General Surgery, Istanbul University Medical Faculty, Istanbul/TR
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Background

Ovarian functions in premenopausal breast cancer patients are frequently affected due to the applied chemotherapy regimen. In this study, we aimed to evaluate the ovarian functions after chemotherapy by assessing the AMH, the number of antral follicle and the volume of ovaries in the premenopausal patients with breast cancer.

Methods

Fifty-one premenopausal operable breast cancer patients who were given adjuvant and neoadjuvant chemotherapy were included in our study. We planned to evaluate the change of serum AMH levels throughout the timeline of the study and ovarian volume-antral follicle numbers measured by transvaginal ultrasonography. First measurements were performed before chemotherapy and repeated in every following 3 months for one-year follow-up period.

Results

Interim third month and initial results of 31 patients were evaluated. Median age: 39 (range: 23-48). The results of 31 patients' 3rd AMH results and the measurements of ovarian volumes and antral follicle numbers of 28 patients were recorded prospectively from database. Initial AMH levels and 3rd follow-up AMH levels were compared revealing statistically significant decrease (p = 0.000). When pre- and post-chemotherapy measurements were compared right and left ovary volumes and antral follicle numbers demonstrated statistically significant decrease after chemotherapy (p = 0.000).

Conclusions

Preliminary data of this study showed that 3rd month AMH levels, antral follicle numbers and ovarian volumes were significantly lower in contrast to pretreatment measurements. By the end of study period we aimed to evaluate the effects of different chemotherapy regimens on ovarian function and predictive strength of utilized markers for evaluation of ovarian function.

Clinical trial identification

Legal entity responsible for the study

Istanbul Bilim University Medical Faculty

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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