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Extended adjuvant temozolamide as prognostic factor of longer overall and progression-free survival in glioblastoma multiforme

Date

09 Oct 2016

Session

Poster display

Presenters

Sara Póvoa

Citation

Annals of Oncology (2016) 27 (6): 103-113. 10.1093/annonc/mdw367

Authors

S.C. Póvoa1, N. Tavares1, M.J. Ribeiro1, D. Azevedo1, A. Coelho1, A. Fernandes1, A. Costa1, C. Caeiro1, B. Carvalho2, P. Linhares2, L. Osório3, L. Castro4, J. Fonseca5, M. Damasceno1

Author affiliations

  • 1 Medical Oncology Department, Hospital de S. João, 4200–319 - Porto/PT
  • 2 Neurosurgical Department, Hospital de S. João, 4200–319 - Porto/PT
  • 3 Radiation Oncology Department, Hospital de S. João, 4200–319 - Porto/PT
  • 4 Pathology Department, Hospital de S. João, 4200–319 - Porto/PT
  • 5 Neuroradiology Department, Hospital de S. João, 4200–319 - Porto/PT
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Resources

Background

Glioblastoma multiforme (GBM), the most common malignant primary central nervous system tumour, has significant morbi-mortality. The aim is to determine prognostic factors (PF) of overall survival (OS) and progression-free survival (PFS) in patients treated with Stupp protocol.

Methods

Retrospective analysis of GBM patients ≥18 years, diagnosed from March 2004 to December 2014, treated with radiotherapy (RT) plus concomitant and adjuvant temozolomide (aTMZ). OS and PFS were assessed by Kaplan-Meier method and multivariate analysis (MA) was performed using Cox regression.

Results

A total of 213 patients completed concomitant TMZ-RT and were included in final analysis. Majority were males (n = 134), with median age of 61 years old (24-84) and 43.1% ECOG performance status 0. Gross total resection (GTR) was possible in 46.9%, partial resection in 33.3% and stereotactic biopsy (SB) in 19.7%. 197 patients proceeded to aTMZ: 107 suspended

Conclusions

Our results suggest an OS and PFS benefit of extended aTMZ beyond standard 6 cycles, with stronger impact in OS with >12 cycles. The retrospective study design limits conclusions and further validation is necessary in prospective randomized studies.

Clinical trial identification

Legal entity responsible for the study

N/A

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.

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