Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display

2168 - Estimation of glomerular filtration rate in patients with abnormal body composition and relation with carboplatin toxicity


09 Oct 2016


Poster display


Marie Bretagne


Annals of Oncology (2016) 27 (6): 497-521. 10.1093/annonc/mdw390


M. Bretagne, A. Jouinot, J. Durand, C. Tlemsani, J. Arrondeau, O. Huillard, P. Boudou Rouquette, F. Goldwasser, J. Alexandre

Author affiliations

  • Department Of Medical Oncology, Cochin Hospital, Paris Descartes University, Ap­hp, Carpem, Certim, Hôpital Cochin, 75014 - Paris/FR


Abstract 2168


Carboplatin clearance is correlated with Glomerular Filtration Rate (GFR), which is usually evaluated with creatinine clearance using Cockcroft-Gault (CG) formula. Because serum creatinine (sCR) level is related to total muscle mass, we hypothesized that an abnormal body composition with a low lean body mass (LBM) percentage (LBM / weight) may result in GFR overestimation and inadequate carboplatin dose calculation by using CG formula. Serum cystatin C (sCY) is an alternative marker of GFR which is not affected by muscle mass. We aimed to correlate GFR creatinine (GFRCr) and cystatin C (GFRCy) to LBM percentage and the risk of toxicity. A high GFRCr/GFRCy ratio might estimate the miscalculation of GFR with sCR.


sCR and sCY were prospectively measured in consecutive cancer patients (pts) before chemotherapy. GFRCr and GFRCy were calculated with CG and GRUBB formula, respectively. The LBM was assessed using CT-scan. Febrile neutropenia and grade 3-4 thrombocytopenia were analysed in a subgroup of pts treated with carboplatin AUC 5 +/- paclitaxel.


In 134 cancer pts (males 51%), median age was 63.7 (20 – 89). In 128 pts without severe renal insufficiency, sCR was correlated with LBM (r = 0.30, Pearson correlation coefficient, p  1.4.


Pts with a low LBM percentage (sarcopenic overweight pts) are at high risk of inadequate calculation of renal function, over dosage of carboplatin and increased acute limiting toxicity. High GFRCr/GFRCy ratio allows to identify these pts.

Clinical trial identification

Legal entity responsible for the study

J. Alexandre


Fondation Martine Midy


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings