Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Efficacy of first-line modified FOLFOX6 with panitumumab or bevacizumab in RAS wild-type/BRAF wild-type metastatic colorectal cancer: impact of tumour symptoms and extent of disease

Date

08 Oct 2016

Session

Poster Display

Presenters

Ferrnando Rivera

Citation

Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370

Authors

F. Rivera1, M. Peeters2, J. Douillard3, J. Taieb4, R. Koukakis5, G. Demonty6, S. Siena7

Author affiliations

  • 1 Department Of Medical Oncology, Hospital Universitario Marques de Valdecilla, 39008 - Santander/ES
  • 2 Department Of Oncology, University Hospital Antwerp, 2650 - Edegem/BE
  • 3 Oncologie Médicale, ICO R. Gauducheau, 44805 - St Herblain/FR
  • 4 Service Hge, Hôpital Européen G.Pompidou, Paris/FR
  • 5 Biostatistics, Amgen Ltd, Uxbridge/GB
  • 6 Medical Development - Oncology, Amgen (Europe) GmbH, Zug/CH
  • 7 Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda and Università degli Studi di Milano, Milano/IT
More

Resources

Background

In patients with previously untreated metastatic colorectal cancer (mCRC), the goal of treatment is likely to influence choice of first-line therapy, as suggested in ESMO 2016 guidelines previewed at WCGIC 2015. We conducted an exploratory analysis of the efficacy of first-line modified FOLFOX6 (mFOLFOX6) plus panitumumab or bevacizumab in patients with RAS wild-type (WT)/BRAF WT mCRC based on the aim of treatment: cytoreduction or disease control.

Methods

PEAK (NCT00819780) was an open-label randomised phase II trial of first-line panitumumab + mFOLFOX6 vs bevacizumab + mFOLFOX6. Using baseline characteristics, patients with RAS WT/BRAF WT mCRC were retrospectively classified into groups according to treatment goal: Cytoreduction group (liver-limited disease [LLD] and/or symptoms) or Disease-control group (asymptomatic with non-liver-limited metastases [with or without liver metastases]). Patients with an Eastern Cooperative Oncology Group (ECOG) score of 1 were considered to have tumour-related symptoms; those with ECOG 2 were excluded as they were not considered fit enough to meet ESMO criteria.

Results

The analysis included 155 patients with RAS WT/BRAF WT mCRC, of whom 83 were in the Cytoreduction group and 72 were in the Disease-control group. Median PFS and OS were numerically longer with panitumumab + mFOLFOX6 vs bevacizumab + mFOLFOX4 in both groups (Table).

Median, months
PFS OS
Cytoreduction group (n = 83)
mFOLFOX6 + 
Panitumumab (n = 42) 12.7 36.8
Bevacizumab (n = 41) 10.6 29.0
HR (95% CI) 0.66 (0.43-1.06) 0.78 (0.46-1.33)
Disease-control group (n = 72)
mFOLFOX6 + 
Panitumumab (n = 35) 13.1 46.1
Bevacizumab (n = 37) 11.5 31.3
HR (95% CI) 0.71 (0.43-1.18) 0.60 (0.33-1.07)

Conclusions

This exploratory analysis suggests that first-line treatment with mFOLFOX6 provides longer PFS and OS when combined with panitumumab than when combined with bevacizumab in patients with RAS WT/BRAF WT mCRC whether the aim of treatment is cytoreduction or disease control. These results are consistent with data from the PRIME study presented elsewhere at this congress (Taieb et al.) using two definitions of ‘symptomatic’, based on ECOG and patient-reported outcomes.

Clinical trial identification

ClinicalTrials.gov: NCT00819780

Legal entity responsible for the study

Amgen

Funding

Amgen

Disclosure

F. Rivera: Acted on advisory boards and received research funding from Amgen, Sanofi, Merck-Serono and Roche. M. Peeters: Received research funding and acted in consultancy/advisory roles for Amgen and received research funding and participated in symposia for Merck Serono J-Y. Douillard: Honoraria/consulting/advisory roles for Amgen, Bayer, Roche, Merck; Research funding from Merck Serono; Travel/accommodation/ expenses from Amgen, Bayer, Roche, Merck. J. Taieb: Honoraria/consultigng/advisory role for Roche, Amgen, Merck, Lilly, Sanofi, Celgene, Sirtex R. Koukakis: Employee of Amgen Ltd. G. Demonty: Employee of Amgen (Europe) GmbH. S. Siena: Member of advisory boards or steering committees or principal investigator for Amgen, Bayer, Boehringer Ingelheim, Celgene, Genentech, Ignyta, Merck, Merrimack, Novartis, Pfzer, Roche, and SanofiAventis.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings