Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Concurrent chemoradiotherapy with paclitaxel and cisplatin in muscle-invasive bladder cancer

Date

09 Oct 2016

Session

Poster display

Presenters

Reham Abdel Wahab

Citation

Annals of Oncology (2016) 27 (6): 266-295. 10.1093/annonc/mdw373

Authors

R. Abdel Wahab1, H.H. Essa1, A. Eltaher2, M. Aboziada3, S. Shehata1

Author affiliations

  • 1 Clinical Oncology, Assiut University Hospitals, 71516 - Assiut/EG
  • 2 Urology, Assiut University Hospitals, 71516 - Assiut/EG
  • 3 Radiotherapy, South Egypt Cancer Institute SECI Assiut University, 7151 - Assiut/EG
More

Resources

Background

There is a debate regarding the optimal chemotherapeutic regimens that can be used concurrently with radiotherapy (Rth) in muscle invasive bladder cancer (MIBC). Taxanes started to be widely used with evidence of response rates improvement when compared to cisplatin. Our aims were to evaluate the tumor response, treatment toxicity, and disease outcome in MIBC patients who treated with concurrent chemo-radiotherapy (CCRTh) either with paclitaxel and cisplatin or cisplatin alone.

Methods

Between July 2007 and December 2010, sixty T2-4a N0 M0 bladder cancer patients were enrolled, of whom 55 were eligible for analysis. We randomized our patients into two group; group I received CCRTh with weekly cisplatin (n = 30) and group II received CCRTH with weekly paclitaxel and cisplatin (n = 25). Kaplan-Meier curve used to estimate overall survival (OS) and recurrence free survival (RFS) with log rank test used to assess the significant difference between patients' subgroups.

Results

A durable complete cure (CR) was achieved in 75% and 87% in group I and II respectively. The 2-year OS and recurrence free survival (RFS) were 60 % and 30% for group I, while, 80 % and 40% for group II, respectively. Multivariate analysis showed that tumor stage was the only survival predictor (P 

Conclusions

Achieving high initial durable CR rates, with acceptable toxicity in both group; showed that addition of paclitaxel to cisplatin did not significantly add benefit to the treatment outcome.

Clinical trial identification

Legal entity responsible for the study

Prof. Samir Shehata

Funding

Assiut University Hospital

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings