Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display

2061 - Comparison of combined chemoradiotherapy regimens; Paclitaxel plus carboplatin and cisplatin plus etoposide for locally advanced non-small-cell lung cancer: A randomized phase III trial


08 Oct 2016


Poster Display


Alper Ata


Annals of Oncology (2016) 27 (6): 411-415. 10.1093/annonc/mdw382


A. Ata1, A. Küçük2, E. Nayir3, Ş. Eskici2

Author affiliations

  • 1 Medical Oncology, Medical Park Hospital, 33000 - Mersin/TR
  • 2 Radiation Oncology, Mersin State Hospital, Mersin/TR
  • 3 Medical Oncology, Necip Fazıl State Hospital, Kahramanmaraş/TR


Abstract 2061


The optimal chemotherapy regimen to use with radiotherapy in stage III non–small-cell lung cancer (NSCLC) is unknown. This phase III comparative randomized trial was conducted to determine the optimal chemotherapy regimen with standard daily concurrent thoracic radiation therapy (CTRT), in patients with locally advanced unresected stage III NSCLC.


We recruited 108 patients aged 18–72 years with stage III, histologically confirmed NSCLC, an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2, an estimated life expectancy of greater than 3 months, and adequate organ function from January 2011 to December 2014. Patients were randomised (1:1) to paclitaxel plus carboplatin and cisplatin plus etoposide arms.


Patients with unresected stages IIIA and IIIB NSCLC received carboplatin (AUC = 2) and paclitaxel (45 mg/m2) given weekly with CTRT (63 Gy) followed by two cycles of consolidation therapy (carboplatin AUC = 6, paclitaxel 200 mg/m2) (arm CP) and cisplatin (50 mg/m2 on days 1, 8, 29, and 36) plus etoposide (50 mg/m2 daily on days 1 to 5, and 29 to 33) with CTRT followed by consolidation cisplatin plus etoposide (arm EP) were included. Ninety nine eligible patients were evaluated. With median follow-up time of 39.4 months, median overall survival was 17.1 and 16.6 months for arms CP and EP, respectively (P = 0.279). But patients in arm EP, compared with patients in arm CP, had more grade 4 neutropenia (18.1% vs 11.1%, p 


In patients with stage III NSCLC treated with cisplatin plus etoposide and carboplatin plus paclitaxel had similar overall survival, but cisplatin plus etoposide arm was associated with increased toxicity.

Clinical trial identification

Legal entity responsible for the study



Turkish Oncology Group


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings