The aim of this study was to investigate the role of circulating tumor cells (CTCs) in assessing and predicting of pathological response to preoperative CRT of rectal cancer.
Sixty-seven patients (average age: 55; male/female: 35/32) with T3-4 and/or N+ rectal cancer were enrolled. All patients received preoperative CRT followed by radical surgery after 6-8 weeks. Blood samples were obtained from patients before and after CRT. CTCs were detected by use of a high-performance size-based micro-fluidic device, which exploited numerous filtered micro-channels in it to enrich the large-sized target tumor cells from whole blood. The pathological results after surgery was evaluated according to tumor regression grade (TRG) classification. The association between CTC counts and the pathological tumor response was analyzed.
CTC counts before CRT were significantly higher than those after CRT (41.24 ± 18.45/5mL vs. 9.7 ± 8.9/5mL, P
Circulating tumor cells are promising markers to predict tumor response after preoperative CRT for rectal cancer.
Clinical trial identification
Legal entity responsible for the study
Fudan University Shanghai Cancer Center
The National Natural Science Foundation of China
W. Sun, Z. Zhang: I identify that no financial interst in products or processes involved in their research.