Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Characterization of the immunoscore of synchronous resected primary tumor and liver colorectal cancer metastases

Date

08 Oct 2016

Session

Poster Display

Presenters

Marc van den Eynde

Citation

Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370

Authors

M. van den Eynde1, B. Mlecnik2, G. Bindea2, J. Machiels1, A. Jouret-Mourin3, P. Baldin3, A. Kartheuser4, D. Leonard4, C. Remue4, J. Gigot4, C. Hubert4, Y. Humblet1, N. Haicheur2, F. Marliot2, F. Pagès2, J. Galon2

Author affiliations

  • 1 Medical Oncology, Cliniques Universitaires St. Luc, 1200 - Brussels/BE
  • 2 Inserm Team 15, Centre de Recherche des Cordeliers, 75006 - Paris/FR
  • 3 Pathology, Cliniques Universitaires St. Luc, 1200 - Brussels/BE
  • 4 Digestive Surgery, Cliniques Universitaires St. Luc, 1200 - Brussels/BE
More

Resources

Abstract 3673

Background

Pooled analysis from previous trials including unresectable metastatic colorectal cancer (mCRC) patients suggests an independent survival benefit of palliative primary tumor resection. Regarding the reported prognostic survival impact of Immunoscore (I) after resection of primary colorectal tumor (PCT) and liver colorectal metastases (LCM), we investigate if (I) could be different in PCT compared to LCM in a subgroup of synchronously resected mCRC patients.

Methods

From a cohort of mCRC patients undergoing curative LCM resection, patients with synchronous resection of LCM and PCT were analyzed. The density of CD3 (T cells) and CD8 (cytotoxic) in the core (CT) and invasive margin (IM) of all synchronous LCM and PCT was quantified with a dedicated image analysis software and used to calculate the CD3/CD8 Immunoscore (I) range from 0 (I0), when low densities of both cell types are found in the CT and IM of the tumor, to 4 (I4) when high densities for both markers are found in both regions. The (I) of the PCT, the mean value of all LCM, the least and the most infiltrated LCM per patient were analyzed and compared using the Fisher's exact test.

Results

Among 161 patients with curative resection of LCM (n = 459), 29 patients (M : 14, F :15 : mean 62,9 y-old) had synchronous LCM (n = 68, mean :2,34/pt) and PCT (n = 29) resection after preoperative treatment (n = 14) or not (n = 15). Low (I) I0-1-2 is significantly associated with PCT compared to the mean of all, the least and the most infiltrated LCM per patient (p 

Conclusions

In patients with synchronously resected PCT and LCM, PCT was significantly associated with a low Immunoscore compared to the LCM. This result would suggest that mCRC patients would indeed benefit from the removal of their low infiltrated PCTs, potential source of future metastases.

Clinical trial identification

Not applicable.

This retrospective study was accepted by the Ethical Committee of the Cliniques universitaires St-Luc where the patients were take in charge.

Legal entity responsible for the study

Jerome Galon and Marc Van den Eynde

Funding

INSERM team 15

Disclosure

All authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings