Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display

3794 - Carboplatin dose based on actual renal function vs. dose capping: no excess of hematotoxicity in treatment of seminoma stage I


09 Oct 2016


Poster display


Martin Fehr


Annals of Oncology (2016) 27 (6): 266-295. 10.1093/annonc/mdw373


M. Fehr1, H. Reichegger1, A. Fischer Maranta2, S. Gillessen1, R. Cathomas2

Author affiliations

  • 1 Medical Oncology/haematology, Kantonsspital St. Gallen, 9007 - St. Gallen/CH
  • 2 Medical Oncology, Kantonsspital Graubünden, 7000 - Chur/CH


Abstract 3794


Single-dose Carboplatin (C) AUC7 is an adjuvant treatment option in Seminoma stage I. Many of these patients have very good renal function and hence high absolute doses of C are frequently administered. Some experts and clinical guidelines recommend capping of C dose at Creatinine-Clearance (Crea-Cl) of 125 ml/min because of concerns of excessive toxicity. The rationale for these concerns has not been explored in patients with Seminoma stage I so far.


Analysis of a cohort of patients with stage I Seminoma treated with C AUC 7 in 2 Swiss centres 2005 – 2015. Main inclusion criteria: Normal blood count at treatment, minimum of 2 measurements during first 8 weeks of follow-up. Comparison of incidence and grade (CTCAE v4.0) of hematological adverse events (AEs) in patients with Crea-Cl  125 ml/min without dose capping.


74 patients with 229 documented measurements were identified. Median age 41 years (Range 22 – 71), Crea-Cl (Cockroft-Gault) 126 ml/min (70 - 206), C dose 1013 mg (700 - 1477). 12 patients with Crea-Cl >125 ml/min and capped C dose (resulting in AUC  vs. G2 11% (4) 29% (6) .31 Decreased White Cell Count 37% (13) 48% (13) .44 Decreased Neutrophil Count 46% (16) 44% (12) .92 Decreased Neutrophil Count >G2 20% (7) 19% (5) .88 AEs with clinical interventions 2.8% (1 hospitalisation with febrile neutropenia G3) 3.7% (1 platelet transfusion in thrombocytopenia G4) .85


Concerns of excessive toxicity in patients with Seminoma stage I and Crea-Cl >125 ml/min treated with adjuvant C AUC7 are not supported by our data. Most AEs were grade 1 (>80%). There was also no statistically significant excess of AEs > grade 2. Therefore capping of C dose is not justified in this Situation.

Clinical trial identification

BASEC Nr. 2016-00472

Legal entity responsible for the study

Kantonsspital St. Gallen, Switzerland, Dr Martin Fehr




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings