Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Capecitabine and streptozocin ± cisplatin for gastroenteropancreatic neuroendocrine tumours: predictors of long-term survival in the NET01 trial

Date

08 Oct 2016

Session

Poster Display

Presenters

Tim Meyer

Citation

Annals of Oncology (2016) 27 (6): 136-148. 10.1093/annonc/mdw369

Authors

T. Meyer1, W. Qian2, J.W. Valle3, D. Talbot4, D. Cunningham5, N. Reed6, L. Wall7, J. Waters8, P. Ross9, A. Anthoney10, K. Sumpter11, N. Sarwar12, T. Crosby13, N. Begum2, G. Young2, R. Hardy2, P. Corrie14

Author affiliations

  • 1 Department Of Oncology, Royal Free London NHS Foundation Trust, NW3 2QG - London/GB
  • 2 Cambridge Cancer Trials Centre, Cambridge Clinical Trials Unit - Cancer Theme, Addenbrooke's Hospital University of Cambridge Hospitals, CB2 0QQ - Cambridge/GB
  • 3 Department Of Medical Oncology, University of Manchester/The Christie NHS Foundation Trust, M20 4BX - Manchester/GB
  • 4 Department Of Oncology, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, OX3 7LE - Oxford/GB
  • 5 Department Of Oncology, The Institute of Cancer Research/Royal Marsden NHS Foundation Trust, SM2 5PT - Sutton/GB
  • 6 Beatson Oncology Centre, Gartnavel General Hospital, G12 0YN - Glasgow/GB
  • 7 Edinburgh Cancer Centre, Western General Hospital, EH4 2XU - Edinburgh/GB
  • 8 Kent Oncology Centre, Maidstone Hospital, ME16 9QQ - Kent/GB
  • 9 Department Of Oncology, Guy's and St. Thomas' Hospital NHS Trust, SE1 9RT - London/GB
  • 10 St James's Institute Of Oncology, St James’s University Hospital, LS9 7TF - Leeds/GB
  • 11 Northern Centre For Cancer Care, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, NE7 7DN - Newcastle upon Tyne/GB
  • 12 Department Of Oncology, Southend University Hospitals NHS Foundation Trust, SS0 0RY - Southend/GB
  • 13 Velindre Cancer Centre, Velindre NHS Trust, CF14 2TL - Cardiff/GB
  • 14 Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust, CB2 0QQ - Cambridge/GB
More

Resources

Abstract 1451

Background

Cytotoxic chemotherapy for advanced, unresectable pancreatic and gastrointestinal foregut neuroendocrine tumours (GEPNETs) commonly comprises 5-fluorouracil (FU) plus streptozocin (S). The NET01 trial, conducted in the pre-kinase inhibitor era, recruited a broad spectrum of patients (pts) to investigate whether capecitabine (Cap) was an acceptable alternative to FU, with or without adding cisplatin (Cis). At median follow up 3.4 years, objective responses (primary endpoint) were reported as similar in the 2 arms, but CapSCis was more toxic. Final progression-free survival (PFS) and overall survival (OS) (secondary endpoints) as well as outcome predictors are now reported with longer follow up.

Methods

Pts with previously untreated advanced, unresectable NETs of pancreatic, gastrointestinal foregut or unknown primary site were randomised to receive three-weekly Cap 625mg/m2 twice daily orally, S 1·0g/m2 IV on day 1, ± Cis 70mg/m2 IV on day 1. Pts could receive the same treatment beyond 6 cycles if there was evidence of benefit. All pts were followed 12 weekly for a minimum of 5 years.

Results

Of 86 (44 CapS, 42 CapSCis) pts randomised, 16% had poorly differentiated histology. With long-term median follow-up of 8 years, 83 (97%) pts have progressed/died and 69 (80%) pts have died. The estimated median PFS was 11.1 months for CapS and 9·6 months for CapSCis (HR = 0.82, 95%CI: 0.53, 1.27). Median OS was 27 months for CapS and 26 months for CapSCis (HR = 0.97, 95%CI: 0.60, 1.56). Three and 5-year OS rates were 40% and 29%, with no difference between arms. Statistically significant factors predicting for OS were tumour Ki67 level, WHO grade and pt age. Addition of Cis to CapS did not appear to influence OS for high grade, poorly differentiated tumours, although numbers are small.

N Overall CapS CapSCis Median OS (yrs) Overall CapS CapSCis
Age (yrs)

Conclusions

PFS and OS were similar for the CapS ± Cis regimens. High patient age, tumour Ki67 and grade all predicted for poorer outcomes.

Clinical trial identification

Legal entity responsible for the study

Cambridge University Hospitals NHS Foundation Trust

Funding

UK NETwork and Cancer Research UK

Disclosure

J.W. Valle: Keocyt (honoraria for Advisory Board in 2010 and 2012) – this relates to streptozocin.

D. Cunningham: Research funding only to RMH from Amgen, AstraZeneca, Bayer, Celgene, Medimmune, Merrimack, Merck Serono, Sanofi. All other authors have declared no conflicts of interest.

Resources from the same session

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.