Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Display

1686 - Brain metastases (BM) in colorectal cancer (CRC): Prognostic factors and survival analysis


08 Oct 2016


Poster Display


Luis del Carpio Huerta


Annals of Oncology (2016) 27 (6): 149-206. 10.1093/annonc/mdw370


L.P. del Carpio Huerta1, M. Tobeña1, A.C. Virgili Manrique1, J. Szafranska2, M. Martín-Richard1, D. Paez1, I. Espinoza2, A. Sebio Garcia1, P. Gomila Pons1, M. Andrés Granyo1, A. Barba Joaquín1, N. Dueñas Cid1, A. Vethencourt Casado1, M.S. García-Cuerva1

Author affiliations

  • 1 Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08026 - Barcelona/ES
  • 2 Pathology, Hospital de la Santa Creu i Sant Pau, 08026 - Barcelona/ES


Abstract 1686


CRC BM are an uncommon event. Some clinical features have been associated with its occurrence but its knowledge remains limited.


We retrospectively analysed CRC patients who developed BM in our center between 1997-2016. Clinical factors (age, performance status [PS], CRC location, stage), RAS/BRAF status and survival were evaluated.


28 patients developed BM and their median age was 64 years (21-81). 82% of the patients had left-sided CRC and 85% had PS0-1. Median time to BM diagnosis from CRC diagnosis was 36 months (m) (1.6-97). 92% of the patients received active treatment (46% whole-brain radiotherapy [WBRT], 46% surgery [S] with or without WBRT). RAS/BRAF were analysed in 60% of cases (47% RAS mutated, 0% BRAF mutated). Median survival (MS) from BM treatment was better for patients who underwent S with or without WBRT than for those treated with WBRT alone (11.3m versus [vs] 6.7m, p = 0.03). This result remained significant in multivariate analysis (MVA) (HR 0.36; 95% confidence interval [CI] 0.14-0.94, p = 0.038). CRC location showed impact on MS from BM treatment (4.6m vs 10.7m, p = 0.017, for right- and left-sided CRC); MVA remained significant (HR 3.19; 95%CI 1.12-13.6, p = 0.032). PS2 and right-sided CRC were associated with shorter time to BM diagnosis: 3.3m vs 43.8m for PS2 and PS0-1 (p 


Surgical treatment of CRC with or without WBRT seems superior to WBRT in terms of survival. Right-sided CRC and PS 2 were associated with worse outcome, while RAS status and other clinical factors had not shown prognostic value.

Clinical trial identification

Legal entity responsible for the study

Hospital de la Santa Creu i Sant Pau


Hospital de la Santa Creu i Sant Pau


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings