Analysis of outcomes and brain metastases (BM) of molecular selected non-small cell lung cancer (NSCLC) patients included in clinical trials

Date

08 Oct 2016

Session

Poster Display

Presenters

Susana Cedres

Citation

Annals of Oncology (2016) 27 (6): 416-454. 10.1093/annonc/mdw383

Authors

S. Cedres, N. Pardo Aranda, A. Martinez de Castro, A. Navarro Mendivil, A. Martinez Marti, C. Ortiz, F. Racca, M. Vilaro, L. Carbonell, A. Piera, I. de la fuente, E. Felip

Author affiliations

  • Medical Oncology, Vall d`Hebron University Hospital Institut d'Oncologia, 08035 - Barcelona/ES
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Resources

Background

The molecular profiling of patients (p) with advanced NSCLC identifies several oncogenic drivers that can be targeted with selective inhibitors. We aimed to assess the characteristics and prognostic factors of p with molecular alterations at our center treated with targeted agents.

Methods

EGFR, KRAS,HER2 mutated p and ALK, ROS1 and RET rearrangements positive p enrolled onto clinical trials between 2009 and 2015 at our center were included in this analysis. A cohort of wild type (WT) adenocarcinoma p was selected as comparator. Survival was estimated by the Kaplan-Meier method.

Results

200 p were collected (76 WT, 45 EGFR, 51 ALK, 21 KRAS, 3 ROS1, 2 HER2 and 2 RET). Median age 57 years (26-82), 52% men, 60% performance status (PS) 1, 59% smokers, 98% stage IV and 92% adenocarcinoma. First treatment was selective inhibitor in 73% of EGFR and 58% of ALK p. Median follow up was 23 months (m) (95% CI 1.6-104.6). The overall survival (OS), still immature with 58% of deaths, was 33m for all p and 57m EGFR, 40m ALK, 31m KRAS and 19m WT. We found differences in OS for molecular selected population vs WT (55m vs 19 m p 

Conclusions

Molecular selected p treated with targeted agents have prolonged survival. Brain metastases is a frequent site of disease progression, but the prognosis of these p is impressive independently of local therapies.

Clinical trial identification

No apply

Legal entity responsible for the study

N/A

Funding

VHIO

Disclosure

All authors have declared no conflicts of interest.

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