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Nintedanib + pemetrexed/cisplatin in malignant pleural mesothelioma (MPM): Phase II biomarker data from the LUME Meso study

Date

13 Apr 2018

Session

New approaches in rare thoracic tumors

Presenters

Nick Pavlakis

Citation

Journal of Thoracic Oncology (2018) 13 (supp_4): S1-S139.

Authors

N. Pavlakis1, F. Grosso2, N. Steele3, A. Nowak4, S. Novello5, S. Popat6, L. Greillier7, M. Reck8, T. Kitzing9, G. Scagliotti5

Author affiliations

  • 1 Northern Cancer Institute, 2065 - St Leonards/AU
  • 2 Department Of Oncology, SS Antonio e Biagio Hospital, Alessandria/IT
  • 3 The Beatson West of Scotland Cancer Centre, Glasgow/GB
  • 4 School Of Medicine, Faculty Of Medicine And Health Sciences, University of Western Australia, Crawley/AU
  • 5 Department Of Oncology, S. Luigi Hospital, University of Turin, Torino/IT
  • 6 Royal Marsden Hospital NHS Foundation Trust, London/GB
  • 7 Assistance Publique - Hôpitaux de Marseille, Aix Marseille University, Marseille/FR
  • 8 Department Of Thoracic Oncology, Lung Clinic Grosshansdorf, Member of the German Center for Lung Research (DZL), Grosshansdorf/DE
  • 9 Boehringer Ingelheim Pharma GmbH & Co KG, Biberach/DE
More

Resources

The randomised Phase II/III LUME-Meso study is evaluating nintedanib + pemetrexed/cisplatin versus placebo + pemetrexed/cisplatin (≤6 cycles), followed by nintedanib or placebo maintenance, in chemo-naïve MPM. In the Phase II part, nintedanib treatment led to improved progression-free survival (PFS; hazard ratio [HR] = 0.54; p = 0.010) and a trend for longer overall survival (OS; HR = 0.77; p = 0.319) compared with placebo. Patients with epithelioid tumours derived greatest benefit. Plasma angiogenic factors and genomic markers were explored for potential associations with treatment outcome in the Phase II epithelioid population.

Resources from the same session

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