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ESMO 2019 Expert Video Report on Malignant Pleural Mesothelioma

Reporting from ESMO Congress 2019, Sanjay Popat comments on results from 3 studies presented in Malignant Pleural Mesothelioma. Considering the results, he thinks that we need to better identify the patients who may benefit from checkpoint inhibitors. In the relapse setting we have modest activity of 22% overall response rate, and to improve those results we should look at checkpoint inhibitors in the front line setting.


  • LBA91: A multicentre randomized phase III trial comparing pembrolizumab (P) vs single agent chemotherapy (CT) for advanced pre-treated malignant pleural mesothelioma (MPM) – results from the European Thoracic Oncology Platform (ETOP 9-15) PROMISE-meso trial
  • LBA92: Switch Maintenance Gemcitabine After First Line Chemotherapy In Patients With Malignant Mesothelioma; A Multicenter Open Label Phase II Trial (NVALT19)
  • 1841O: 2nd/3rd-line Nivolumab vs Nivo plus Ipilimumab in Malignant Pleural Mesothelioma: long-term results of IFCT-1501 MAPS2 phase 2R trial with a focus on hyperprogression (HPD)

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