Chapter 1 – Pathology and Classification
Summary: Pathology and classification
- STSs represent <1% of all malignant tumours
- Histological classification of STSs is based on the line of differentiation
- IHC is used to determine line of differentiation in STSs
- IHC can also be used as a surrogate for specific molecular alterations
- Most STSs are histologically graded (Grade 1, 2 or 3) according to FNCLCC
- Primary bone sarcomas account for only 0.2% of all neoplasms
- A multidisciplinary approach with correlation between radiological features and morphology is mandatory for a correct diagnosis in bone tumours
- Grading of most bone sarcomas is determined according to histological subtype
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