26P - Pre and post chemotherapy circulating oxidative stress parameters in breast cancer patients

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Breast Cancer
Translational Research
Presenter Dariush Moslemi
Citation Annals of Oncology (2016) 27 (suppl_9): ix1-ix8. 10.1093/annonc/mdw573
Authors D. Moslemi1, S. Mahjoub2, M. Taherkhani2, A. Karkhah2
  • 1Radiation Oncology, Babol University of Medical Sciences (BUMS), 47176-47745 - Babol/IR
  • 2Biochemistry, Babol University of Medical Sciences (BUMS), 47176-47745 - Babol/IR

Abstract

Background

Previous studies have suggested the importance of serum oxidant/antioxidant status in initiation and progression of breast cancer. The present study aimed to evaluated oxidative and nitrosative stress markers in breast cancer patients and the impact of age and clinical stage on these variables before and after three cycle chemotherapy using AC-T

Methods

This study included 60 women with newly diagnosed breast cancer in stage II, III who underwent AC-T chemotherapy regimen as the first therapy after surgery. Serum samples were obtained before treatment and after three cycles of chemotherapy. Then, the serum status of total antioxidant status (TAS), thiobarbituric acid reacting substances (TBARS), carbonyl proteins content and total nitric oxide (NOx) were analyzed by spectrophotometry. In addition, BMI was measured and analyzed according to age-related effects and clinical stage of the disease.

Results

A concurrent increase in TBARS, carbonyl, NOx and a significant decrease in TAS were also observed after third course of chemotherapy using AC-T. In addition, these findings indicated that there was not a significant change in BMI of patients after three cycle chemotherapy using AC-T, whereas some changes were found in the status of oxidative and nitrosative stress markers which were associated with age and clinical stage of the disease

Conclusions

Our data indicated that AC-T chemotherapy regimen increases the oxidative and nitrosative stress in breast cancer patients. Therefore, monitoring of serum oxidative and nitrosative markers may be helpful for screening of breast cancer patients with high risk of early disease progression and predictive or prognostic markers

Clinical trial indentification

Legal entity responsible for the study

Babol University of Medical Sciences

Funding

Babol University of Medical Sciences

Disclosure

All authors have declared no conflicts of interest.