247P - Impact of the preoperative neutrophil-to-lymphocyte ratio in the short term outcomes of patients with gastric cancer

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Gastric Cancer
Translational Research
Presenter Ryoichi Miyamoto
Citation Annals of Oncology (2016) 27 (suppl_9): ix68-ix85. 10.1093/annonc/mdw582
Authors R. Miyamoto, S. Inagawa, N. Sano, S. Tadano, M. Yamamoto
  • Department Of Gastroenterological Surgery, Tsukuba Medical Center Hospital, 305-8558 - Tsukuba/JP

Abstract

Background

Not only experimental evidence but also growing clinical evidence support an association between the systemic inflammatory response and the progression of various malignancies, including gastric cancers, colorectal cancers, lung cancers, demonstrating an inverse correlation with patient survival. The preoperative neutrophil-to-lymphocyte ratio (NLR) is known to be a strong predictor of mortality in patients with gastric cancer. However, the utility of preoperative NLR to predict short term outcomes in gastric cancer patients remains unclear. Therefore, the aim of our study was to determine whether the preoperative NLR is a predictive value of short term outcome in gastric cancer patients.

Methods

One hundred resected gastric cancer patients were retrospectively enrolled. Median NLR was calculated, and 2.7 was set as cut-off value. The patients were then divided into two groups: high-NLR group (n = 47) and low-NLR group (n = 53). The patient characteristics and perioperative outcomes were respectively compared between the two groups. In addition to the preoperative NLR, we also employed the Estimation of Physiological Ability and Surgical Stress (E-PASS) scoring system and Glasgow prognostic score (GPS) as a predictor of postoperative complications.

Results

Among low-NLR group and high-NLR group, significant differences were respectively observed in perfomance status (0.05 ± 0.30, 0.30 ± 0.69; p = 0.018), E-PASS score (0.20 ± 0.25, 0.30 ± 0.29; p = 0.121), GPS (0.18 ± 0.44, 0.38 ± 0.60; p = 0.003), TMN stage (p = 0.001). In terms of postoperative complications, Clavien-Dindo’s Grade III-V complications [2 (3.7%), 11 (23.4%); p = 0.015], and intraoperative blood loss (151 ± 179, 248 ± 403; p = 0.022) among low-NLR group and high-NLR group.

Conclusions

The present study indicated that the preoperative NLR influenced short term outcomes including postoperative complications and intraoperative blood loss in gastric cancer patients. The preoperative NLR is a useful predictive value of short term outcome in gastric cancer patients.

Clinical trial indentification

None.

Legal entity responsible for the study

Tsukuba Medical Center Hospital ethics committee approved this study.

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.