37P - Expression pattern of cyclooxygenase-2 in carcinoma of cervix

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Cervical Cancer
Translational Research
Presenter Shahin Hameed
Citation Annals of Oncology (2016) 27 (suppl_9): ix9-ix18. 10.1093/annonc/mdw574
Authors S. Hameed, V. Nair
  • Pathology, Amala institute of medical sciences, 680555 - Thrissur/IN

Abstract

Background

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over 20 years ago.In the past decade, however, more progress has been made in understanding the role of cyclooxygenase enzymes in biology and disease than at any other time in history. The most solid, unequivocal and well-established role of COX-2 in the gastrointestinal system is its participation in colon cancer. It has been found that approximately 50% of adenomas and 80-85% of adenocarcinomas show increased expression of COX-2. Cancer of the cervix has been the most important cancer in women in India over the past two decades. Until now, only a few studies has been undertaken to evaluate the role of COX-2 in carcinomas of cervix. This study is undertaken to evaluate the role of COX-2 in carcinomas of cervix by studying the expression pattern in different types of carcinomas.

Methods

This was a hospital based descriptive study conducted in the Department of Pathology, Amala Institute of Medical Sciences, Thrissur over a period of two years. Fifty-one (51) cases of cervical carcinoma were studied which included 7 cases of cervical intraepithelial neoplasias, 42 invasive squamous cell carcinomas, and 1 case of adenocarcinoma. Formalin-fixed paraffin-embedded tissue sections were stained by Hematoxylin and Eosin. Immunohistochemistry for COX-2 were performed on these blocks.

Results

COX-2 showed a higher expression pattern in invasive squamous cell carcinoma than in CIN (P = 0.010). One case of adenocarcinoma showed strong positivity and intensity of staining for COX-2 antibody than invasive squamous carcinomas. Among the histopathological correlates, tumor differentiation did not show a positive correlation (P = 0.47). Lymphovascular invasion and lymphnode metastatic were associated with positive COX-2 staining

Conclusions

The expression of COX-2 was found to be more in cases of invasive than in CIN. Adenocarcinomas showed a strong expression of COX-2. However, no association of COX-2 expression and the presence of lymphovascular emboli and lymph node metastasis were found in the present study. COX-2 inhibitors need to be studied as a therapeutic adjunct for the treatment of carcinoma cervix.

Clinical trial indentification

Legal entity responsible for the study

Amala Institute of Medical Sciences

Funding

Self

Disclosure

All authors have declared no conflicts of interest.