560P - A next-generation sequencing analysis indicates genomic alterations in pathological morphologies: A genomic case report of pulmonary carcinosarcoma...

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Hayato Koba
Citation Annals of Oncology (2016) 27 (suppl_9): ix181-ix183. 10.1093/annonc/mdw602
Authors H. Koba, H. Kimura, Y. Amino, N. Terada, H. Matsuoka, S. Nishikawa, T. Yoneda, Y. Tambo, T. Sone, K. Kasahara
  • Respiratory Medicine, Kanazawa University, 920-8641 - Kanazawa/JP

Abstract

Background

Lung carcinosarcoma is a rare malignancy of lung cancers and little analyses is performed for identification of the genomic alterations including oncogenic drivers.

Methods

Postoperative material from 129 patients with RCC has been studied. The average age of the patients was 57.8 ± 9.7 years. DLI in PZ was evaluated at a 1000x magnification in 5 fields of view using tissue specimens stained with hematoxylin and eosin. Statistical analysis was carried out using the program Statistica 6.1.

Results

We found a correlation between DLI and: 1) TNM stage (r = 0.312; p

Conclusions

Based on our findings, we believe that high DLI in PZ found in RCC patients can be attributed as a negative prognostic marker.

Clinical trial indentification

Legal entity responsible for the study

The Ethics Committee of Kanazawa University Hospital (#327)

Funding

Kanazawa University Respiratory Medicine

Disclosure

All authors have declared no conflicts of interest.