170O - Lymph node status as a prognostic factor after palliative resection of metastatic colorectal cancer

Date 19 December 2016
Event ESMO Asia 2016 Congress
Session Gastrointestinal tumours
Topics Colon and Rectal Cancer
Rectal Cancer
Pathology/Molecular Biology
Surgical oncology
Presenter Qingguo Li
Citation Annals of Oncology (2016) 27 (suppl_9): ix53-ix67. 10.1093/annonc/mdw581
Authors Q. Li1, S. Cai2
  • 1Department Of Colorectal Cancer, Shanghai Cancer Center Fudan University, 200032 - Shanghai/CN
  • 2Colorectal Surgery, Shanghai Cancer Center Fudan University, 200032 - Shanghai/CN

Abstract

Background

Lymph node (LN) status is one of the most important predictors for M0 colorectal cancer patients. However, its clinical impact on stage IV colorectal cancer remains unclear. The aim of this study was to explore the prognostic value of lymph node status after palliative resection of primary colorectal tumor. Lymph node (LN) status is one of the most important predictors for M0 colorectal cancer patients. However, its clinical impact on stage IV colorectal cancer remains unclear. The aim of this study was to explore the prognostic value of lymph node status after palliative resection of primary colorectal tumor.

Methods

Surveillance, Epidemiology and End Results (SEER)-registered metastatic colorectal cancer patients diagnosed between 2004 and 2010 were included in this study. Survival rate was generated using Kaplan-Meier curves, and the differences were compared with the log-rank test. A Cox proportional hazards regression model was then built to evaluate the risks of variables on CSS in colorectal cancer patients. The results were validated in additional 392 patients from Fudan University Shanghai Cancer Center (FUSCC).

Results

A total of 17,553 patients with CRC were identified in SEER database. X-tile program identified 2 and 10 as optimal cutoff values to divide patients into high, middle and low risk. N stage and negative lymph node counts were validated as independent prognostic factors in both univariate and multivariate analyses, and even in subgroup analysis of each N stage (P 

Conclusions

Primary tumor lymph node status was a strong predictor of CSS after palliative resection of metastatic colorectal cancer. Advanced N stage and small NLN count were high risk of cancer related death after palliative resection of primary tumor.Standard LN dissection may still necessary for palliative resection of metastatic colorectal cancer.

Clinical trial indentification

Legal entity responsible for the study

Qingguo Li

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.