94P - Influence of different treatment planning techniques on radiation doses to the heart, left anterior descending coronary artery and lungs in the rad...

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Breast Cancer, Early Stage
Surgical oncology
Presenter Farimah Hadjilooei
Citation Annals of Oncology (2016) 27 (suppl_9): ix19-ix29. 10.1093/annonc/mdw575
Authors F. Hadjilooei1, P. Haddad1, B. Kalaghchi1, F. Amouzgar Hashemi1, M. Esfahani2, H. Nedaie2, S. Shahriaran3, M. Babaei4, F. Farhan4
  • 1Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, 13145-158 - Tehran/IR
  • 2Radiotherapy Physics Department, Cancer Institute, Tehran University of Medical Sciences, 13145-158 - Tehran/IR
  • 3Radiology Department, Cancer Institute, Tehran University of Medical Sciences, 13145-158 - Tehran/IR
  • 4Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, 13145-158 - Tehran/IR

Abstract

Background

Breast-conserving surgery (BCS) followed by radiotherapy (RT) to the breast is now an acceptable standard of care for the majority of women with early-stage breast cancer. But evidence has long been accumulating that RT doses to the heart can result in premature ischemic heart disease. In this study 3 different RT techniques were compared for heart, left anterior descending coronary artery (LAD) and lung doses in left breast cancer patients after breast-conserving surgery.

Methods

Three different plans were designed for each patient using conventional tangential fields, 6 + 18 MV combination beams, and filed-in-field (FIF) technique. These were compared in terms of doses to the planning target volume (PTV), ipsilateral lung, heart and LAD.

Results

Forty left breast cancer patients were included in this study. Mean PTV V95% was 95.74% for conventional, 90.45% for FIF and 87.89% for 6 + 18 MV (p 

Conclusions

The results of our study indicated that the FIF and 6 + 18 MV combination techniques significantly reduced the doses received by the heart, LAD and left lung compared to conventional tangential fields, while FIF was superior in general to 6 + 18 MV considering the above variables. The lower doses to the organs at risk were achieved in these plans with a small but statistically significant loss in PTV coverage.

Clinical trial indentification

94-02-207-29322 Tehran University of Medical Sciences

Legal entity responsible for the study

Radiation Oncology Research Center, Tehran University of Medical Sciences

Funding

Tehran University of Medical Sciences

Disclosure

All authors have declared no conflicts of interest.